Advertisement

Biotechnology and Human Tumor Nucleolar Antigens

  • Harris Busch
  • Rose K. Busch
  • James W. Freeman
  • Robert Larson
  • Mohammed Haidar
  • Sissy Jhiang
  • Benigno Valdez
  • Wei-Wei Zhang

Abstract

Cancer cells and most normal resting cells have been readily differentiated for a century by morphologic and biologic criteria but biochemical and immunologic distinctions have not yet withstood the test of time (Busch, 1984).

Keywords

HeLa Cell P120 mRNA Nucleolar Protein P120 cDNA Hepatoma Ascites Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Busch H. 1984a, One genes and other new targets for cancer chemotherapy. J. Cancer Res. Clin. Oncol., 107:1.CrossRefGoogle Scholar
  2. Busch H. 1984b, Molecular lesions in cancer. Mol. & Cell. Biochem., 61:111.Google Scholar
  3. Busch R. K. and Busch H. 1977, Antigenic proteins of nucleolar chromatin of Novikoff hepatoma ascites cells. Tumori, 63:347.Google Scholar
  4. Freeman J. W., Busch R. K., Gyorkey F., Gyorkey P., Ross B. E., and Busch H. 1988, Identification and characterization of a human proliferation—associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase. Cancer Res., 48:1244.Google Scholar
  5. Freeman J. W., Busch R. K., Ross B. E., and Busch H. 1985, Masking of nontumorous antigens for development of human tumor nucleolar antibodies with improved specificity. Cancer Res. 45:5637.Google Scholar
  6. Freeman J. W., McRorie D. K., Busch R. K., Gyorkey F., Gyorkey P., Ross B. E., Spohn W. H., and Busch H. 1986, Identification and partial characterization of a nucleolar antigen with a molecular weight of 145,000 found in a broad range of human cancers. Cancer Res., 46:3593.Google Scholar
  7. Haidar M. A., Henning D., and Busch H. The upstream sequence -537 to -278 is necessary for transcription of early G1 proliferating cell nucleolar antigen PI20 gene. In manuscript.Google Scholar
  8. Hazlewood J., Fonagy A., Henning D, Freeman J. W., Busch R. K., and Busch H. 1989, mRNA levels for human nucleolar protein pi20 in tumor and nontumor cells. Cancer Commun., 01:29.Google Scholar
  9. Ochs R. L., Reilly M. T., Freeman J. W., and Busch H. 1988, Intranucleolar localization of human proliferating cell nucleolar antigen p120. Cancer Res., 48:6523.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Harris Busch
    • 1
  • Rose K. Busch
    • 1
  • James W. Freeman
    • 1
  • Robert Larson
    • 1
  • Mohammed Haidar
    • 1
  • Sissy Jhiang
    • 1
  • Benigno Valdez
    • 1
  • Wei-Wei Zhang
    • 1
  1. 1.Department of PharmacologyBaylor College of MedicineHoustonUSA

Personalised recommendations