Selective Effects of T-2 Toxin and Ochratoxin a on Immune Functions

  • Michael J. Taylor
  • Raghubir P. Sharma
  • Michael I. Luster


Mycotoxins have been reported to alter immune responses in experimental animals.12,19 The selective effects of various trichothecene mycotoxins and the ochratoxins on the immune system have gained attention recently.13,14,23 Herein, we have reviewed some of our findings on the trichothecene mycotoxins, particularly T-2 toxin (T-2). Data on the Ochratoxins A and B will also be discussed.


Natural Killer Cell Activity Natural Killer Activity Fusarium Toxin Trichothecene Mycotoxin Bone Marrow Necrosis 
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  1. 1.
    Bendele AM, Carlton WW, Krogh P, Lillehoj EB, 1985, Ochratoxin carcino-genesis in the (C57BL/6J)F1 mouse, J Natl Cancer Inst.,75:733–742.Google Scholar
  2. 2.
    Besedovsky HO, Del Rey A, Sorkin E, 1983, Neuroendocrine immune-regulation, In: “Immunoregulation”, Fabaris W, Garaci E, Hadden J, Michison NA, eds, Plenum Press, New York.Google Scholar
  3. 3.
    Calogero AE, Gallucci WT, Chrousos GP, Gold PW, 1988, Catecholamine effects upon rat hypothalamic corticotropin-releasing hormone secretion in vivo, J Clin Invest., 82:839–846.CrossRefGoogle Scholar
  4. 4.
    Carroll BJ, Person MJ, Martin FIR, 1986, Evaluation of three acute tests of hypothalamic-pituitary-adrenal function, Metabolism, 18:476–483.CrossRefGoogle Scholar
  5. 5.
    Claman HN, 1972, Corticosteroids and lymphoid cells, New Engl J Med., 287:388–397.CrossRefGoogle Scholar
  6. 6.
    Cooray R, Lindahl-Kiessling K, 1987, Effect of T-2 toxin on the spontaneous antibody-secreting cells and other non-lymphoid cells in the murine spleen, Fd Chem Toxic., 25:25–29.CrossRefGoogle Scholar
  7. 7.
    Corrier DE, Ziprin RL, Mollenhauer HH, 1987, Modulation of cell-mediated resistance to Listeriosis in mice given T-2 toxin, Toxicol Appl Pharmacol., 89:323–331.CrossRefGoogle Scholar
  8. 8.
    Frometin H, Salazar-Mejicanos S, Mariat F, 1980, Pouvoir pathogene de Canidia albicans pour la souris normale ou deprimee par une mycotoxine: le diacetoxyscirpenol, Ann Microbiol (Inst Past.),131B:39–46.Google Scholar
  9. 9.
    Kabir S, Rosenstreich DL, Mergenhagen SE, 1978, Bacterial endotoxins and cell membranes, In: “Bacterial Toxins and Cell Membranes”, Academic Press, New York.Google Scholar
  10. 10.
    Kanai K, Kondo E, 1984, Decreased resistance to mycobacterial infection in mice fed a trichothecene compound (T-2 toxin), Jap J Med Sci Biol., 37:97–104.Google Scholar
  11. 11.
    Keppler D, Pausch J, Decker K, 1974, Selective uridine triphosphate deficiency induced by D-galactosamine in liver and reversed by pyrimidine nucleotide precursors: Effect on ribonucleic acid synthesis, J Biol Chem., 249:211–216.Google Scholar
  12. 12.
    Luster MI, Blank JA, 1987, Molecular and cellular basis of chemically induced immunotoxicity, Ann Rev Pharmacol., 27:23–49.CrossRefGoogle Scholar
  13. 13.
    Luster MI, Germloc Dr, Burleson GR, Jameson CW, Ackerman MF, Lamm K J, Hayes HT, 1987, Selective immunosuppression in mice of natural killer cell activity by ochratoxin A, Cancer Res., 47:2259–2263.Google Scholar
  14. 14.
    Otokawa M, 1983 Immunological disorders, In: “Trichothecenes, Biological and Toxicological Aspects, Developments in Food Science, Vol. 3”, Ueno Y, ed., Elsevier Press, New York.Google Scholar
  15. 15.
    Rosenstein Y, Lafarge-Frayssinet C, 1983, Inhibitory effect of Fusarium T2-toxin on lymphoid DNA and protein synthesis, Toxicol Appl Pharmacol., 70:283–288.CrossRefGoogle Scholar
  16. 16.
    Rosenstein Y, Lafarge-Frayssinet C, Lespinats G, Loisillier F, Lafont P, Frayssinet C, 1979, Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis sand skin grafts of crude extracts, T - toxin and diacetoxyscirpenol, Immunology, 36:111–117.Google Scholar
  17. 17.
    Rosenstein Y, Kretschmer RR, Lafarge-Frayssinet C, 1981, Effect of Fusarium toxins, T-2 toxin and diacetoxyscirpenol on murine T-Independent immune responses, Immunology, 44:555–560.Google Scholar
  18. 18.
    Seyberth HW, Schmidt-Gayk H, Hackenthal E, Toxicity, clearance and distribution of endotoxin in mice as influenced by actinomycin D, cycloheximide, a-amanitin and lead acetate, Toxicon, 10:491–500.Google Scholar
  19. 19.
    Sharma RP, Reddy RV, 1987, Toxic effects of chemicals on the immune system, In: “Handbook of Toxicology”, Haley JJ, Bernt WO, eds., Hemisphere, Washington, DC.Google Scholar
  20. 20.
    Suneja SK, Ram GC, Wagle DS, 1983, Effects of feeding T-2 toxin on RNA, DNA and protein contents of liver and intestinal mucosa of rats, Toxicol Lett., 18:73–76.Google Scholar
  21. 21.
    Suneja SK, Wagle DS, Ran GC, 1987, Effects of T-2 toxin gavage on the synthesis and contents of rat liver macromolecules, Fd Chem Toxic., 25:387–392.CrossRefGoogle Scholar
  22. 22.
    Szafarczyk A, Guillaume V, Conte-Devoix B, Alonso G, Malaval F, Pares-Herbute N, Oliver C, Assenmacher I, 1988, Central Catechola- minergic system stimulates secretion of CRH at different sites, Am J Physiol., 255:E463–E468.Google Scholar
  23. 23.
    Tai JH, Pestka JJ, 1988, Synergistic interaction between the trichothecene T-2 toxin and Salmonella typhimurium lipopolysac- charide in C3H/HeN and C3H/HeJ mice. Toxicol Lett., 44:191–200.CrossRefGoogle Scholar
  24. 24.
    Taylor MJ, Pang VF, Beasley VR, 1989, The immunotoxicity of tricho-thecene mycotoxins, In: “Trichothecene Mycotoxicosis: Pathophysio-logic Effects”, Beasley VR, Ed., CRC Press Inc., Boca Raton, FL.Google Scholar
  25. 25.
    Taylor MJ, Reddy RV, Sharma RP, 1985, Immunotoxicity of repeated low level exposure to T-2 toxin, a trichothecene mycotoxin, in CD-I mice, Myco Res., 1:57–64.CrossRefGoogle Scholar
  26. 26.
    Taylor MJ, Smart RA, Sharma RP, 1989, Relationship of the hypothalamic- pituitary-adrenal axis with chemically induced immunomodulation. I. Stress-like response after exposure to T-2 toxin, Toxicology, 56:179–197.CrossRefGoogle Scholar
  27. 27.
    Taylor MJ, Warren RP, Sharma RP, 1989, Relationship of the hypothalamic- pituitary-adrenal axis with chemically induced immunomodulation. II. Effects of T-2 toxin on T-dependent and T-independent antibody responses in adrenalectomized mice. Toxicology, (in press).Google Scholar
  28. 28.
    Ziprin RL, Holt PS, Mortensen RF, 1987, T-2 toxin effects of the serum amyloid P-component (SAP) response of Listeria monocytogenes- and Salmonella typhimurium-infected mice, Toxicol Lett.,39:1;77–184.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Michael J. Taylor
    • 1
  • Raghubir P. Sharma
    • 2
  • Michael I. Luster
    • 1
  1. 1.National Toxicology ProgramNIH, NIEHSUSA
  2. 2.Toxicology ProgramUtah State UniversityLoganUSA

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