Subcellular Distribution and Macromolecular Binding of Aflatoxin in Fetal and Neonatal Rat Liver

  • S. Kumagai
  • Y. Ito
  • M. Iwaki
  • A. Nagahara
  • Y. Omata


The aflatoxins are mycotoxins produced by several species of Aspergillus, aflatoxin B1 (B1) being the most potent hepatotoxic and hepatocarcinogenic compound among these metabolites. There is a wide variation in susceptibility to B1 among animal species and sexes.23 Considerable research has been undertaken on biochemical mechanisms of the action of aflatoxin in relation to the species and sex differences. Formation of B1-8,9-epoxide by the cytochrome P-450 enzyme system and subsequent binding to DNA are regarded as critical steps of the carcinogenic effect of B1. 1,21,24,29,31 The importance of formation of the B1-glutathione conjugate by cytosolic glutathione S-transferase in inactivation of B1-epoxide has been well documented in relation to species and sex differences of the B1 effects. 3,4,18,22,27


Subcellular Distribution Cytosolic Glutathione Hepatic Cytosol Packard Inst Hepatic Macromolecule 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • S. Kumagai
    • 1
  • Y. Ito
    • 1
  • M. Iwaki
    • 1
  • A. Nagahara
    • 1
  • Y. Omata
    • 1
  1. 1.National Institute of HealthTokyoJapan

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