Genetics of Thermostable Direct Hemolysin of Vibrio Parahaemolyticus

  • Mitsuaki Nishibuchi
  • James B. Kaper

Abstract

Vibrio parahaemolyticus causes seafood-borne gastroenteritis and is responsible for about half of bacterial food poisoning cases in Japan.1 It also has been recognized as an important agent of gastroenteritis in other parts of the world.2-4 Although many possible virulence factors have been suggested to explain the pathogenic mechanism of the organism, the thermostable direct hemolysin (TDH) has been considered the major virulence factor based on epidemiological findings.5-6 TDH is toxic to various cultured cells and lethal to small experimental animals, and is a potent cardiotoxin, but its enterotoxic mechanism is not understood.7

Keywords

Agar Recombination Polypeptide Kato Vibrio 

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Mitsuaki Nishibuchi
    • 1
  • James B. Kaper
    • 2
  1. 1.Department of MicrobiologyKyoto UniversityKyotoJapan
  2. 2.Center for Vaccine Development Division of Geographic Medicine Department of MedicineUniversity of Maryland School of MedicineBaltimoreUSA

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