Growth Rate Increase in Normal Wistar Rats Catalyzed by Insulin

  • Paul W. Wang

Abstract

Suboptimal growth and development are major factors limiting more efficient output of consumer food products derived from agriculturally important animals. New approaches are being developed through advances in biotechnology, and analogs to pituitary growth hormones made by rDNA have been shown to enhance growth by daily injections at a dose of 2 mg/100kg body weight. Pancreatic insulin is also an anabolic hormone which can be readily formulated in the form of sustained release implants. In a study with 4 groups of 10 normal Wistar rats each, implants made of 12% bovine insulin in palmitic acid were used to maintain hypoglycemia at 3.1 ± 0.7 mM/L in one group, and another group was injected daily with a 12 U dose which induced hypoglycemia for ~8 hr. In a 14-day period, the controls gained about 10.6 ± 8.5 g, the insulin injected group showed an increase of 21.3 ± 12.6 g in body weight, while the animals with implant grew 29.3 ± 11 g with about 10% higher food consumption. Since the hypoglycemia caused no apparent ill effects, the results suggest a feasible alternative to the pituitary hormones in catalyzing growth rate of animals in agriculture.

Keywords

Placebo Sugar Carbohydrate Lactate Cage 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    P. J. Eppard, D. E. Bauman & S. N. McCutcheon, J. Dairy Sci., 68, 1109 (1985).CrossRefGoogle Scholar
  2. 2.
    Product Information Booklet on Humatrope — Somatotropin (rDNA origin) for Injection, Eli Lilly and Co., Indianapolis, IN, 1987.Google Scholar
  3. 3.
    P. Y. Wang, to be published.Google Scholar
  4. 4.
    F. S. Greenspan, C. H. Li, M. E. Simpson & H. M. Evans, Endocrinology, 45, 455 (1949).CrossRefGoogle Scholar
  5. 5.
    M. D. Groesbeck, A. F. Parlow & W. H. Daughaday, Endocrinology, 120, 1963 (1987).CrossRefGoogle Scholar
  6. 6.
    T. J. Fronk, C. J. Peel, D. E. Bauman & R. C. Gorewit, J. Animal Sci., 57, 699 (1983).Google Scholar
  7. 7.
    M. N. Sillence private communications.Google Scholar
  8. 8.
    P. Y. Wang, Diabetes, 36, 1068 (1987).CrossRefGoogle Scholar
  9. 9.
    P. Y. Wang, ASATO Transactions, 33, 319 (1987).Google Scholar
  10. 10.
    M. J. Hageman, Abstract of Paper, 194th ACS Meeting, MBTD 12, (1987).Google Scholar
  11. 11.
    K. Prestele, M. Franetzki & H. Kresse, Diabetes Care, 3, 362 (1980).CrossRefGoogle Scholar
  12. 12.
    M. N. Sillence & P. Y. Wang, to be published.Google Scholar
  13. 13.
    J. M. Salter, I. W. F. Davidson & C. H. Best, Can. J. Biochem. Physiol., 35, 913 (1957).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Paul W. Wang
    • 1
  1. 1.Laboratory of Chemical Biology Institute of Biomedical Engineering Faculty of MedicineUniversity of TorontoTorontoCanada

Personalised recommendations