Abstract
The hallmark of an infection with human immunodeficiency virus (HIV) is a selective depletion of CD4+ lymphocytes and an associated progressive decline of immunological function to the point the host becomes overwhelmed by opportunistic infections or malignancies (McChesney and Oldstone, 1989; Schupbach, 1989). Since CD4+ cells are essential components of effective host defense against most of the systemic mycotic agents, patients with acquired immunodeficiency syndrome (AIDS) frequently suffer from fulminating fungal infections (Armstrong, 1988; Spencer and Jackson, 1989). The two dimorphic fungi which are most commonly isolated from individuals infected with HIV are Histoplasma capsulatum and Coccidioides immitis, (Armstrong, 1988; Spencer and Jackson, 1989; Cairns, 1988) but less frequently other dimorphic fungi such as Sporothrix schenckii, (Bibler et al., 1986; Kurosawa et al., 1988) and Paracoccidioides brasiliensis (Bakos et al., 1989) have been reported to be secondary invaders in AIDS patients. To understand the AIDS patients’ immunological responses to the opportunistic fungi, it is essential to first recognize the immunological status of the host at the onset of the fungal infection. So, before discussing the specific immune responses during systemic dimorphic fungal infections in AIDS patients, I want to define the state of immune function as an HIV infection progresses from the asymptomatic, seroconversion stage to AIDS and identify the stage(s) at which the host is most vulnerable to opportunistic infections. For this purpose, I will use the classification scheme proposed by the Walter Reed group which is based upon the classical immunological and clinical status of HIV infected persons.
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References
Alterman, D.D., and Cho, K.C., 1988, Histoplasmosis involving the omentum in an AIDS patient: CT demonstration, J. Comput. Assist. Tomogr., 12:664.
Anaissie, E., Fainstein, V., Samo, T., Bodey, G.P., and Sarosi, G.A., 1988, Central nervous system histoplasmosis, Am. J. Med., 84:215.
Armstrong, D., 1988, Life-threatening opportunistic fungal infection in patients with acquired immunodeficiency syndrome, Ann. N.Y. Acad. Sci., 544:443.
Bakos, L., Kronfeld, M., Hampe, S., Castro, I., and Zampese, M., 1989, Disseminated paracoccidioidomycosis with skin lesions in a patient with acquired immunodeficiency syndrome, J. Am. Acad. Dermatol., 20:854.
Bibler, M.R., Luber, H.J., Glueck, H.I., and Estes, S.A., 1986, Disseminated sporotrichosis in a patient with HIV infection after treatment for acquired factor VIII inhibitor, J.A.M.A., 256:3125.
Bonner, J.R., Alexander, W.J., Dismukes, W.E., App, W., Griffin, F.M., Little, R., and Shin, M.S., 1984, Disseminated histoplasmosis in patients with the acquired immune deficiency syndrome, Arch. Intern. Med., 144:2178.
Byrne, W.R., and Dietrich, R.A., 1989, Disseminated coccidioidomycosis with peritonitis in a patient with acquired immunodeficiency syndrome, Arch. Intern. Med., 149:947.
Cairns, M.R., 1988, Fungal infections in the acquired immunodeficiency syndrome, J. Electron. Microsc. Tech., 8:115.
Graham, A.R., Sobony, R.E., Bronnimann, D.A., and Galgiani, J.N., 1988, Quantitative pathology of coccidioidomycosis in acquired immunodeficiency syndrome, Hum. Pathol., 19:800.
Graybill, J.R., 1988, Histoplasmosis and AIDS, J. Infect. Dis., 158:623.
Johnson, P.C., Khardori, N., Najjar, A.F., Butt, F., Mansell, P.W.A., and Sarosi, G.A., 1988, Progressive disseminated histoplasmosis in patients with acquired immunodeficiency syndrome, Am. J. Med., 85:152.
Kurosawa, A., Pollock, S.C., Collins, M.P., Kraff, C.R., and Tso, M.O.M., 1988, Sporothrix schenckii endophthalmitis in a patient with human immunodeficiency virus infection, Arch. Ophthalmol., 106:376.
Macher, A.M., 1988, The pathology of AIDS, Public Health Rep., 103:246.
Masur, H., Ognibene, F.P., Yarchoan, R., Shelhamer, J.H., Baird, B.F., Travis, W., Suffredini, A.F., Deyton, L., Kovacs, J.A., Falloon, J., Davey, R., Polis, M., Metcalf, J., Baseler, M., Wesley, R., Gill, V.J., Fauci, A.S., and Lane, H.C., 1989, CD4 counts as predictors of opportunistic pneumonias in human immunodeficiency virus (HIV) infection, Ann. Intern. Med., 111:223.
McChesney, M.B., and Oldstone, M.B.A., 1989, Virus-induced immunosuppression: infection with measles virus and human immunodeficiency virus, Adv. Immunol., 45:335.
Salzman, S.H., Smith, R.L., and Aranda, C.P., 1988, Histoplasmosis in patients at risk for the acquired immunodeficiency syndrome in a nonendemic setting, Chest, 93:916.
Schupbach, J., 1989, Human retrovirology. Facts and concepts, Curr. Top. Microbiol. Immunol., 142:36.
Spencer, P.M., and Jackson, G.G., 1989, Fungal and mycobacterial infections in patients infected with the human immunodeficiency virus, Antimicrob. Chemother., 23 Suppl. A:107.
Tornita, T., and Chiga, M., 1988, Disseminated histoplasmosis in acquired immunodeficiency syndrome: light and electron microscopic observations, Hum. Pathol., 19:438.
Wheat, L.J., Slama, T.G., and Zeckel, M.L., 1985, Histoplasmosis in the acquired immune deficiency syndrome, Am. J. Med., 78:203.
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© 1990 Plenum Press, New York
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Murphy, J.W. (1990). Immunological Aspects of Dimorphic Fungi in AIDS. In: Bossche, H.V., Mackenzie, D.W.R., Cauwenbergh, G., Van Cutsem, J., Drouhet, E., Dupont, B. (eds) Mycoses in AIDS Patients. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0655-9_19
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DOI: https://doi.org/10.1007/978-1-4613-0655-9_19
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