Inhibition of Phospholipase A2 by Uteroglobin and Antiflammin Peptides

  • Lucio Miele
  • Eleonora Cordella-Miele
  • Antonio Facchiano
  • Anil B. Mukherjee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 279)

Abstract

Blastokinin (1) or uteroglobin (UG; 2) is a secretory protein with a low molecular mass (15.8 kDa). This protein was originally discovered in the rabbit uterine fluid during early pregnancy (1, 2). Its synthesis and secretion in the endometrium are stimulated by progesterone (2–5). Since its discovery in 1967, UG has been one of the most thoroughly studied markers of progesterone action in the rabbit endometrium. In addition to the uterus, UG has been found in several other organs of rabbits, namely, the oviduct, the male genital tract and the tracheobronchial tree of both male and female animals (4–9). More recently, we detected UG in the circulation of the rabbit (10). The source of this protein in circulation seems to be the tracheobronchial epithelium and/or the progesterone-induced uterine endometrium (10).

Keywords

Surfactant Proline Dexamethasone Prostaglandin Luminal 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Krishnan, R.S., and Daniel, Jr. J.C. 1967 Science 158: 490.PubMedCrossRefGoogle Scholar
  2. 2.
    Beier, H.M. 1969 Biochem Biophys. Acta 160: 289.Google Scholar
  3. 3.
    Arthur, A.T., and Daniel, Jr. J.C. 1972. Fertil. Steril. 23: 115.PubMedGoogle Scholar
  4. 4.
    Kay, E., and Feigelson, M. 1974. Biochem. Biophys. Acta. 271: 436.Google Scholar
  5. 5.
    Petzoldt, U., Dames, W., Grottschweski, G.H.M, and Neuhoff, V. 1972. Cytobiology 5: 272.Google Scholar
  6. 6.
    Beier, H.M., Bohn, H., and Muller, W. 1975 Cell Tissue Res. 165: 1.PubMedCrossRefGoogle Scholar
  7. 7.
    Kirchner, C. 1976. Cell Tissue Res. 170: 415.PubMedCrossRefGoogle Scholar
  8. 8.
    Kirchner, C., and Schroer, H.G. 1976. J. Reprod. Fertil. 47: 325.PubMedCrossRefGoogle Scholar
  9. 9.
    Noske, I.G., Feigelson, M. 1976 Biol. Reprod. 15: 704.PubMedCrossRefGoogle Scholar
  10. 10.
    Kikukawa, T., and Mukherjee, A.B. 1989. J. Cell Mol. Endocrinol. 62: 177.CrossRefGoogle Scholar
  11. 11.
    Nieto, A., Ponstingl, H., and Beato, M. 1977. Arch. Biochem. Biophys. 180: 82.PubMedCrossRefGoogle Scholar
  12. 12.
    Ponstingl, H., Nieto, A, and Beato, M. 1978. Biochemistry 17: 3908.PubMedCrossRefGoogle Scholar
  13. 13.
    Popp, R.A., Foresman, K.R., Wise, L.D., and Daniel, Jr., J.C. 1978. Proc. Natl. Acad. Sci. U.S.A. 75: 5516.PubMedCrossRefGoogle Scholar
  14. 14.
    Atger, M., Mercier, J.C., Haze, G., Fridlansky, F., and Milgrom, E. 1979. Biochem. J. 177: 985.PubMedGoogle Scholar
  15. 15.
    Mornon, J.P., Fridlansky, F., Bally, R., and Milgrom, E. 1980. J. Mol. Biol. 127: 415.CrossRefGoogle Scholar
  16. 16.
    Morize, I., Surcouf, E., Vaney, M.C., Epelboin, Y., Buehner, M., Fridlansky, R., Milgrom E., and Mornon, J.P., 1987. J. Mol. Biol. 194: 725.PubMedCrossRefGoogle Scholar
  17. 17.
    Aumuller, G., Seitz, J., Heyns, W., and Kirchner, C. 1985. Histochemistry 83: 413.PubMedCrossRefGoogle Scholar
  18. 18.
    Warembourg, M., Tranchant, O., Atger, M., and Milgrom, E. 1986. Endocrinology 119: 1632.PubMedCrossRefGoogle Scholar
  19. 19.
    Mayol, R.F., and Longenecker, D.E. 1974. Endocrinology 95: 1534.PubMedCrossRefGoogle Scholar
  20. 20.
    Shirai, E., Izuka, R., and Notake, Y. 1972. Fertil. Steril. 23: 522.PubMedGoogle Scholar
  21. 21.
    Daniel, Jr. J.C. 1971. Adv. Biosci. 6: 191.Google Scholar
  22. 22.
    Daniel, Jr. J.C. 1972. Fertil. Steril. 23: 522.Google Scholar
  23. 23.
    Wolf, D.P., and Mastroianni, Jr. L. 1975. Fertil. Steril. 26: 240.PubMedGoogle Scholar
  24. 24.
    Voss, H.G., and Beato, M. 1977. Fertil. Steril. 28: 972.PubMedGoogle Scholar
  25. 25.
    Cowan, B.C., North, D.H., Whitworth, N.S., Fujita, R., Schumacher, U.K., and Mukherjee, A.B. 1986. Fertil. Steril. 45: 820.PubMedGoogle Scholar
  26. 26.
    Kikukawa, T., Cowan, B.C., Tejada, R.I., and Mukherjee, A.B 1988. J. Clin. Endocrinol. Metab. 67: 315.PubMedCrossRefGoogle Scholar
  27. 27.
    Dhannireddy, R., Fujita, R., and Mukherjee, A.B. 1988 Biochem Biophys. Res. Commun. 152: 1447.CrossRefGoogle Scholar
  28. 28.
    Manyak, M., Kikukawa, T., and Mukherjee, A.B. 1988, J. Urol. 140: 176.PubMedGoogle Scholar
  29. 29.
    Miele, L., Cordella-Miele, E., and Mukherjee, A.B. 1987. Endocrine Rev. 8: 474.CrossRefGoogle Scholar
  30. 30.
    Challis, J.R.G., Davies, I.J., and Ryan, K.J. 1973. Endocrinol. 93: 971.CrossRefGoogle Scholar
  31. 31.
    Janne, O., Isomaa, V.V., Torkkeli, T.K., Isotalo, H.E., and Kopu, H.T. 1983. In: Wayne Bardin, C., Milgrom, E., and Mauvais-Jarvis, P. (eds) Progesterone and Progestins. Raven Press New York, p 33.Google Scholar
  32. 32.
    Chilton, B. S., Mani, S. K. and Bullock, D. W. 1988. Mol. Endocrinol. 2: 1169.PubMedCrossRefGoogle Scholar
  33. 33.
    Goswami, A., and Feigelson, M. 1974. Endocrinology 95: 669.PubMedCrossRefGoogle Scholar
  34. 34.
    Bochskanl, R., and Kirchner, C. 1981. Wilh. Roux Arch. Dev. Biol. 190: 127.CrossRefGoogle Scholar
  35. 35.
    Mukherjee, A. B., Cordella-Miele, E., Kikukawa, T., and Miele, L. 1988. In: Zappia, V., Galletti, P., Porta R., and Wold, F. (eds) Advances in Post-translational Modifications of Proteins and Ageing. Plenum Publishing, New York, pp. 135–152.Google Scholar
  36. 36.
    Mukherjee, A.B., Laki, Ki, and Agrawal, A. K. 1980. Med. Hypoth. 6: 1043.CrossRefGoogle Scholar
  37. 37.
    Siiteri, P.K., Febris, F., Clemens, L.E., Chang, R.J., Gondos, B., and Stites, D. 1977. Ann. N.Y. Acad. Sci. 286: 384.PubMedCrossRefGoogle Scholar
  38. 38.
    Mukherjee, D.C., Ulane, R.E., Manjunath, R., and Mukherjee, A.B. 1983. Science 219: 989.PubMedCrossRefGoogle Scholar
  39. 39.
    Mukherjee, A.B., Ulane, R.E., and Agrawal, A.K. 1982. Amer. J. Reprod. Immunol. 2: 135.Google Scholar
  40. 40.
    Mukherjee, A.B., Cunningham, D., Agrawal, A.K., and Manjunath, R. 1982. Ann. N.Y. Acad. Sci. 392: 401.CrossRefGoogle Scholar
  41. 41.
    Manjunath, R., Chung, S.I., and Mukherjee, A.B. 1984. Biochem. Biophys. Res. Commun. 121: 400.PubMedCrossRefGoogle Scholar
  42. 42.
    Schiffman, E., Geetha, V., Pencev, D., Warabi, H., Mato, J., Hirata, F., Brownstein, M., Manjunath, R., Mukherjee, A.B., Liotta, L., and Terranova, V.P. 1983. In: Keller, H., Till E.D. (eds) Agents and Actions Supplements. Birkhauser Verlag, Basel, Vol. 12: 106.Google Scholar
  43. 43.
    Schiffman, E., Geetha, V., Pencev, D., Mato, J., Garcia-Castro, I., Chiang, P.K., Manjunath R. and Mukherjee, A.B. 1984. In: Kay, A.B., Frank Austen K., Lichtenstein, L.M. (eds). Asthma: Physiology, Immunopharmacology and treatment. Third International Symposium. Academic Press, London, p. 173.Google Scholar
  44. 44.
    Vasanthakumar, A., Manjunath, R., Mukherjee, A.B., Warabi, H., and Schiffman, E. 1988. Biochem. Pharmacol. 37: 389.PubMedCrossRefGoogle Scholar
  45. 45.
    Manjunath, R., Levin, S.W., Kumaroo, K.K., Butler, J.DeB., Donlon, J., McDonald, H., Fujita, R, Schumacher, U.K., and Mukherjee, A.B. 1987. Biochem. Pharmacol. 36: 741.PubMedCrossRefGoogle Scholar
  46. 46.
    Flower, R.J., and Blackwell, G.J. 1979. Nature 275: 456.CrossRefGoogle Scholar
  47. 47.
    Hirata, F., Schiffman, E., Venkatasubramanian, K., Solomon, D. and Axelrod, J.A. 1980. Proc. Natl. Acad. Sci. USA 77: 2535.Google Scholar
  48. 48.
    DiRosa, M., Flower, R. J., Hirata, F., Parente, L., and Russo-Marie, F. 1984. Prostaglandins 28: 441.CrossRefGoogle Scholar
  49. 49.
    Levin, S.W., Butler, J. DeB, Schumacher, U.K., Wightman, P.D., and Mukherjee, A.B. 1986. Life Sci. 38: 1813.PubMedCrossRefGoogle Scholar
  50. 50.
    Benveniste, J. and Pretolani, M. 1985. In: Russo-Marie, F., Mencia-Huerta J.M., and Chignard, M. (eds). Advances in Inflammation. Research. Raven Press, New York, Vol. 10: 7.Google Scholar
  51. 51.
    Bourne, H. R. 1989. Nature 337: 504.PubMedCrossRefGoogle Scholar
  52. 52.
    Gramzow, M., Schroeder, H., Fritsche, U., Kurelec, B., Robitzki, A., Zimmermann, H., Friese, K., Kreuter, M. H., and Muller, W. E. G. 1989. Cell 59: 939.PubMedCrossRefGoogle Scholar
  53. 53.
    Guinea, R., Lopez-Rivas, A., and Carrasco, L. 1989. J. Biol. Chem. 264: 21923.PubMedGoogle Scholar
  54. 54.
    Wallner, B. P., Mattaliano, R.J., Hession, C., Cate, R. L., Tizard, R., Sinclair, L. K., Foeller, C., Chow, E. P., Browning, J. L., Ramachandran, K. L., Pepinsky, R. B. 1986. Nature 320: 77.PubMedCrossRefGoogle Scholar
  55. 55.
    Crompton, M. R., Moss, S. E. and Crumpton, M. J. 1988. Cell 55: 1.PubMedCrossRefGoogle Scholar
  56. 56.
    Miele, L., Cordella-Miele, E., Facchiano, A., and Mukherjee, A. B. 1988. Nature 335: 726.PubMedCrossRefGoogle Scholar
  57. 57.
    Weber, K., and Johnson, N. 1986 FEBS Lett. 203: 95.PubMedCrossRefGoogle Scholar
  58. 58.
    Geisow, M.J. 1986 Febs Lett. 203: 99.PubMedCrossRefGoogle Scholar
  59. 59.
    Wilbur, W.J., and Lipman, D.J. 1983. Proc. Natl. Acad. Sci. USA. 80: 726.PubMedCrossRefGoogle Scholar
  60. 60.
    Cirino, G., Flower, R.J., Browning, J.L., Sinclair, L.K., and Pepinsky, R.B. 1987. Nature, 328: 270.PubMedCrossRefGoogle Scholar
  61. 61.
    Davidson, F.F., Dennis E.A., Powell, M., and Glenney, J.R. Jr. 1987. J. Biol. Chem. 262: 1698.PubMedGoogle Scholar
  62. 62.
    Haigler, H.T., Schlaepfer, D.D., and Burgess, W.H. 1987 J. Biol. Chem. 262: 6921.PubMedGoogle Scholar
  63. 63.
    Slotboom, A. J., Verger, R., Verheij, H. M., Baartsman, P. H. M., Van Deenen, L. L. M., and De Haas, G. H. 1976. Chem. Phys. Lipids 17: 128.PubMedCrossRefGoogle Scholar
  64. 64.
    Deems, R. A., Eaton, B., and Dennis, E. A. 1975. J. Biol. Chem. 250: 9013.PubMedGoogle Scholar
  65. 65.
    Lutz, R. A., Bull, C. and Rodbard, D. 1986. Enzyme 36: 197.PubMedGoogle Scholar
  66. 66.
    Romero, G., Thompson, K. and Biltonen, R. L. 1987. J. Biol. Chem. 262: 13476.PubMedGoogle Scholar
  67. 67.
    Gheriani-Gruszka, N., Almog, S., Biltonen, R. L. and Lichtenberg, D. 1988. J. Biol. Chem. 263: 11808.PubMedGoogle Scholar
  68. 68.
    Bell, J. D. and Biltonen, R. L. 1989. J. Biol. Chem. 264: 12194.PubMedGoogle Scholar
  69. 69.
    Cho, W., Tomasselli, A. G., Heinrikson, R. L. and Kezdy, F. J. 1988. J. Biol. Chem. 263: 11237.PubMedGoogle Scholar
  70. 70.
    Tomasselli, A. G., Hui, J., Fisher, J., Zurcher-Neely, H., Reardon, I. M., Oriaku, E., Kezdy, F. J. and Heinrikson, R. L. 1989. J. Biol. Chem. 264: 10041.PubMedGoogle Scholar
  71. 71.
    Camussi, G., Tetta, C., Bussolino, F., and Baglioni, C. 1990. J. Exp. Med. 171: 913.PubMedCrossRefGoogle Scholar
  72. 72.
    Chan, C., Ni, M., Miele, L., Mukherjee, A. B., Nussenblatt, R. B. 1990. 5th International Symposium on the Immunology and Immunopathology of the Eye. Tokyo, March 13–15, 1990.Google Scholar
  73. 73.
    Ialenti, A., Doyle, P. M., Hardy, G. N., Simpkin, D. S. E., and DiRosa, M. 1990. Agents and Actions 29: 48.PubMedCrossRefGoogle Scholar
  74. 74.
    Vostal, J., Mukherjee, A. B., Miele, L., and Shulman, N. R. 1989. Biochem. Biophys. Res. Commun.165: 27.PubMedCrossRefGoogle Scholar
  75. 75.
    Sudhoff, T.C., Slaughter, C.A., Leznicki, I., Barion, P., and Reynolds, G.A. 1988. Proc. Natl. Acad. Sci. USA 85: 664.CrossRefGoogle Scholar
  76. 76.
    Kretsinger, R. H., and Creutz, C. E. 1986. Nature 320: 573.PubMedCrossRefGoogle Scholar
  77. 77.
    Davidson, F. F., Lister, M. D., and Dennis, E. A. 1990. J. Biol Chem. 265: 5602.PubMedGoogle Scholar
  78. 78.
    Ahn, N. G., Teller, D. C., Bienkowski, M. J., McMullen, B. A., Lipkin, E. W., and De Haen, C. 1988. J. Biol. Chem. 263: 18657.PubMedGoogle Scholar
  79. 79.
    Errasfa, M., Bachelet, M., and Russo-Marie, F. 1988. Biochem. Biophys. Res. Commun. 153: 1267.PubMedCrossRefGoogle Scholar
  80. 80.
    Cirino, G., Peers, S. H., Flower, R. J., Browning, J. L., and Pepinsky, R. B. 1989. Proc. Natl. Acad. Sci. USA 86: 3428.PubMedCrossRefGoogle Scholar
  81. 81.
    Drust, D. S., and Creutz, C. E. 1988. Nature 331: 88.PubMedCrossRefGoogle Scholar
  82. 82.
    Hirata, F. 1983. Adv. Prostaglandin, Thromboxane, Leukotriene Res. 11: 73.Google Scholar
  83. 83.
    Pepinsky, R. B., Tizard, R., Mattaliano, R., Sinclair, L. K., Miller, G. L., Browning, J. L., Chow, E. P., Burne, C., Huang, K., Pratt, D., Watcher, L., Hession, C., Frey, A.Z., and Wallner, B. P., 1988. J. Biol. Chem. 263: 10799.PubMedGoogle Scholar
  84. 84.
    Creutz, C. E., Zaks, W. J., Hamman, H.C., Crane, S., Martin, W. H., Gould, K. L., Oddie, K. M., and Parsons, S. J. 1987. J. Biol. Chem. 262: 1860.PubMedGoogle Scholar
  85. 85.
    Nakano, T., Hanasaki, K. and Arita, H. 1989. J. Biol. Chem. 264: 5400.PubMedGoogle Scholar
  86. 86.
    Metafora, S., Facchiano, F., Facchiano, A., Esposito, C., Peluso, G., and Porta, R. 1987. J. Prot. Chem. 6: 353.CrossRefGoogle Scholar
  87. 87.
    Porta, R., Esposito, C., Persico, P., Peluso, G. and Metafora, S. 1988. In: Zappia, V., Galletti, P., Porta, R., and Wold, F., (eds). Advances in Posttranslational modification of Proteins and Aging. Plenum Press, New York. Vol. I.Google Scholar
  88. 88.
    Paonessa, G., Metafora, S., Tajana, G., Abrescia, P., De Santis, A., Gentile, V. and Porta, R. 1984. Science 226: 852.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Lucio Miele
    • 1
  • Eleonora Cordella-Miele
    • 1
  • Antonio Facchiano
    • 1
  • Anil B. Mukherjee
    • 1
  1. 1.Section on Developmental GeneticsHuman Genetics Branch, NICHD, NIHBethesdaUSA

Personalised recommendations