Past Present and Future of Gonadotropins
The cornerstone to the conquest of infertility was laid in the beginning of this century. It took however nearly 80 years of work of many scientists from all over the globe to slowly unravel the puzzle of nature’s most guarded secret, the control of the reproductive processes. Physiologists, biochemists, surgeons and physicians engaged in fundamental and applied research funded by international and national organizations, hand in hand with the pharmaceutical and diagnostic industries have slowly been able to reduce the often quoted figure of 12% infertility to a point that barely 2% of previously infertile women will not be able to experience motherhood.
KeywordsGrowth Hormone Ovarian Response Infertile Woman Ovulation Induction GnRH Antagonist
Unable to display preview. Download preview PDF.
- Borth, R., Lunenfeld, B., and Menzi, A., 1961, Pharmacologic and clinical effects of a gonadotropin preparation from human postmenopausal urine, in: “Human Pituitary Gonadotropins,” A. Albert and M.C. Thomas, eds., Springfield.Google Scholar
- Crowe, S.J., Cushing, H., and Homans, J., 1966, Cited by Lunenfeld, B. and Donini, P., Historic aspects of gonadotrophins, in: “Ovulation,” R.B. Greenblatt, ed., J.B. Lipincott Co., Toronto.Google Scholar
- Donini, P., Puzzuoli, D., and Montezemolo, R., 1964, Purification of gonadotropin from human menopausal urine, Acta Endocr. (Kbh), 45:329.Google Scholar
- Franchimont, P., Aimer, S., Mannaerts, B., Boen, P., and Kicivic, P.M., 1989, New GnRH antagonist ORG 30850: The first clinical experience, Gynecol. Endocrinol., 3:(suppl. 1)13.Google Scholar
- Lunenfeld, E., and Lunenfeld, B., 1988, Modern approaches to the diagnosis and management of anovulation, Int. J. Fert., 33:308.Google Scholar
- Menashe, Y., Pariente, C., Lunenfeld, B., Dan, U., Frenkel, Y., and Mashiach, S., 1989, Does endogenous growth hormone reserve correlate to ovarian response to human menopausal gonadotropins, Isr. J. Med. Sci. 25:296.Google Scholar