Follicular Rupture During Ovulation: Activation of Collagenolysis

  • A. Tsafriri
  • D. Daphna-Iken
  • A. O. Abisogun
  • R. Reich


The preovulatory surge of gonadotropins induces a series of orderly sequenced changes in the mature ovarian follicle. These include resumption of oocyte meiosis, luteinization of the follicle and finally the rupture of follicle wall and release of a fertilizable ovum. While initial studies on follicular response to gonadotropins dealt primarily with changes in steroidogenesis and resumption of meiosis, recently the biochemical changes associated with follicular rupture have been investigated


Plasminogen Activator Granulosa Cell Collagenase Activity Collagenolytic Activity Human Granulosa Cell 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • A. Tsafriri
    • 1
  • D. Daphna-Iken
    • 1
  • A. O. Abisogun
    • 1
  • R. Reich
    • 1
  1. 1.Department of Hormone ResearchThe Weizmann Institute of ScienceRehovotIsrael

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