Abstract
Xeroderma pigmentosum (XP), is a rare autosomal recessive disorder with increased sun sensitivity, multiple pigmentary abnormalities and a more than 1000-fold increased frequency of cancer of the sun exposed portions of the skin and eyes. Cultured cells from XP patients are hypersensitive to the cytotoxic and mutagenic effects of UV radiation and have defective DNA repair (reviewed in Robbins et al, 1974; Kraemer and Slor, 1985; Kraemer, 1987; Cleaver and Kraemer, 1989).
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© 1990 Plenum Press, New York
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Kraemer, K.H. et al. (1990). Defective DNA Repair in Humans: Clinical and Molecular Studies of Xeroderma Pigmentosum. In: Sutherland, B.M., Woodhead, A.D. (eds) DNA Damage and Repair in Human Tissues. Basic Life Sciences, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0637-5_7
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DOI: https://doi.org/10.1007/978-1-4613-0637-5_7
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