Effects of Caloric Restriction on the Maintenance of Genetic Fidelity
Comparative analysis of DNA damage and repair determinations across different species can contribute to a better understanding of the biological significance of these parameters in human tissues.Previous data from such comparative studies, used inconjunction with additional data from a number of other areas (including life span studies) has led to one approach which considers DNA damage and repair in the context of longevity-assurance mechanisms (Sacher, 1977; Hart and Turturro, 1981). The theory of longevity-assurance mechanisms treats animal life span as the by-product of particular processes which have evolved to protect the genomic integrity of a species. These processes, such as DNA repair and limiting proliferation, would also protect cells from neoplastic transformation. Moreover, human evolution of what appears to be the longest mammalian life span may have been integrally dependent upon these processes, and an understanding of these mechanisms seems critical to the discovery of methods to improve longevity and limit toxicity from a number of environmental exposures.
KeywordsObesity Toxicity Adduct Testosterone Dimethyl
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- Kirkwood, T., 1985, Comparative and evolutionary aspects of longevity, in: “Handbook of the Biology of Aging”, C. Finch and E. Schneider, eds., Van Nostrand, New York.Google Scholar
- Leakey, J., Cunny, H., Bazare, J. Jr., Webb, P., Lipscomb, J., Slikker, W. Jr., Feuers, R., Duffy, P. H., and Hart, R. W., 1989, Effects of aging and caloric restriction on hepatic drug metabolizing systems in the Fischer 344 rat. II. effects on conjugating enzymes. Mech. Ageing Dev., 48: 157.PubMedCrossRefGoogle Scholar
- Nakamura, K.D., Duffy, P.H., Lu, M., and Hart, R.W., Hepatic myc protooncogene is reduced and possibly correlated with body temperature in fasted Peromyscus leucopus mice., AGE, in press.Google Scholar
- Newberne, P.M., and Rogers, A.E., 1986, The role of nutrients in cancer causation, in: “Diet, Nutrition, and Cancer,” Y. Hsyashi, ed., Japan Soc. Press, Tokyo.Google Scholar
- Sacher, G., 1977, Life table modification and life prolongation, in: “Handbook of the Biology of Aging”, C. Finch and L. Hayflick, eds., Van Nostrand, New York.Google Scholar
- Schneider E.L., and Reed, J.D., 1985, Modulations of aging processes. in: “Handbook of the Biology of Aging”, C. Finch and E. Schneider, eds., Van Nostrand, New York.Google Scholar
- Turturro, A., and Hart, R.W., 1984, DNA repair mechanisms in aging, in: “Comparative Biology of Major Age-Related Diseases,” D. Schiapelli and G. Migaki, eds., Liss, New York.Google Scholar