Effects of Caloric Restriction on the Maintenance of Genetic Fidelity

  • Ronald W. Hart
  • Angelo Turturro
  • Rex A. Pegram
  • Ming W. Chou
Part of the Basic Life Sciences book series (BLSC, volume 53)


Comparative analysis of DNA damage and repair determinations across different species can contribute to a better understanding of the biological significance of these parameters in human tissues.Previous data from such comparative studies, used inconjunction with additional data from a number of other areas (including life span studies) has led to one approach which considers DNA damage and repair in the context of longevity-assurance mechanisms (Sacher, 1977; Hart and Turturro, 1981). The theory of longevity-assurance mechanisms treats animal life span as the by-product of particular processes which have evolved to protect the genomic integrity of a species. These processes, such as DNA repair and limiting proliferation, would also protect cells from neoplastic transformation. Moreover, human evolution of what appears to be the longest mammalian life span may have been integrally dependent upon these processes, and an understanding of these mechanisms seems critical to the discovery of methods to improve longevity and limit toxicity from a number of environmental exposures.


Caloric Restriction Brown Norway Increase Life Span Aberrant Gene Expression Peromyscus Leucopus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bishop, J., 1985, Viral oncogenes, Cell, 42: 23.PubMedCrossRefGoogle Scholar
  2. Croy, R.G., and Wogan, G.N., 1981, Temporal Patterns of Covalent DNA Adducts in Rat Liver after Single and Multiple Doses of Aflatoxin B1, Cancer Res., 41: 197.PubMedGoogle Scholar
  3. Duffy, P.H., Feuers, R.J., Leakey, J.A., Turturro, A., and Hart, R.W., 1989, Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat, Mech. Ageing Dev., 48: 117.PubMedCrossRefGoogle Scholar
  4. Harman, D., 1981, The aging process. Proc. Natl. Acad. Sci. 78: 7124.PubMedCrossRefGoogle Scholar
  5. Hart, R.W., and Turturro, A., 1981, Evolution and longevity- assurance processes, Naturwissenschaften, 68: 552.PubMedCrossRefGoogle Scholar
  6. Howard, P.C., Heflich, R.H., Evans, F.E., and Beland, F.A., 1983, Formation of DNA Adducts in vitro and in Salmonella typhimurium upon Metabolic Reduction of the Environmental Mutagen 1-Nitropyrene, Cancer Res., 43: 2052.PubMedGoogle Scholar
  7. Kirkwood, T., 1985, Comparative and evolutionary aspects of longevity, in: “Handbook of the Biology of Aging”, C. Finch and E. Schneider, eds., Van Nostrand, New York.Google Scholar
  8. Koizumi, A., Weindruch, R., and Walford, R.L., 1987, Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice, J. Nutr., 117: 361.PubMedGoogle Scholar
  9. Leakey, J., Cunny, H., Bazare, J. Jr., Webb, P., Lipscomb, J., Slikker, W. Jr., Feuers, R., Duffy, P. H., and Hart, R. W., 1989, Effects of aging and caloric restriction on hepatic drug metabolizing systems in the Fischer 344 rat. II. effects on conjugating enzymes. Mech. Ageing Dev., 48: 157.PubMedCrossRefGoogle Scholar
  10. Lindahl, T. and Nyberg, B., 1972, Rate of depurination of native deoxyribonucleic acid, Biochemistry, 11: 3610.PubMedCrossRefGoogle Scholar
  11. Lipman, J.M., Turturro, A., and Hart, R.W., 1989, The influence of dietary restriction on DNA repair in rodents: A preliminary study, Mech. Ageing Dev. 48: 135.PubMedCrossRefGoogle Scholar
  12. Nakamura, K.D., Duffy, P.H., Turturro, A., and Hart, R.W., 1989, The effect of dietary restriction on myc protooncogene expression in mice: A preliminary study, Mech. Ageing Dev. 48: 199.PubMedCrossRefGoogle Scholar
  13. Nakamura, K.D., Duffy, P.H., Lu, M., and Hart, R.W., Hepatic myc protooncogene is reduced and possibly correlated with body temperature in fasted Peromyscus leucopus mice., AGE, in press.Google Scholar
  14. Newberne, P.M., and Rogers, A.E., 1986, The role of nutrients in cancer causation, in: “Diet, Nutrition, and Cancer,” Y. Hsyashi, ed., Japan Soc. Press, Tokyo.Google Scholar
  15. Pashko, L.L., and Schwartz, A., 1983, Effect of food restriction, dehydroepiandrosterone, or obesity on the binding of 3H-7,12-dimethyl-benz(a)anthracene to mouse skin DNA. J. Gerontol. 38: 8.PubMedGoogle Scholar
  16. Pegram R.A., Allaben W.T., and Chou, M.W., 1989, Effect of caloric restriction on aflatoxin-B1 DNA adduct formation and associated factors in Fischer 344 rats: Preliminary findings., Mech. Ageing Dev. 48: 167.PubMedCrossRefGoogle Scholar
  17. Sacher, G., 1977, Life table modification and life prolongation, in: “Handbook of the Biology of Aging”, C. Finch and L. Hayflick, eds., Van Nostrand, New York.Google Scholar
  18. Schneider E.L., and Reed, J.D., 1985, Modulations of aging processes. in: “Handbook of the Biology of Aging”, C. Finch and E. Schneider, eds., Van Nostrand, New York.Google Scholar
  19. Turturro, A., and Hart, R.W., 1984, DNA repair mechanisms in aging, in: “Comparative Biology of Major Age-Related Diseases,” D. Schiapelli and G. Migaki, eds., Liss, New York.Google Scholar
  20. Wong, Z.A., and Hsieh, D.P.H., 1980, The comparative metabolism and toxicokinetics of aflatoxin B1 in the monkey, rat, and mouse, Toxicol. Appl. Pharmacol. 55: 115.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Ronald W. Hart
    • 1
  • Angelo Turturro
    • 1
  • Rex A. Pegram
    • 1
  • Ming W. Chou
    • 1
  1. 1.National Center for Toxicological ResearchUnited States Public Health ServiceJeffersonUSA

Personalised recommendations