Effects of Caloric Restriction on the Maintenance of Genetic Fidelity
Comparative analysis of DNA damage and repair determinations across different species can contribute to a better understanding of the biological significance of these parameters in human tissues.Previous data from such comparative studies, used inconjunction with additional data from a number of other areas (including life span studies) has led to one approach which considers DNA damage and repair in the context of longevity-assurance mechanisms (Sacher, 1977; Hart and Turturro, 1981). The theory of longevity-assurance mechanisms treats animal life span as the by-product of particular processes which have evolved to protect the genomic integrity of a species. These processes, such as DNA repair and limiting proliferation, would also protect cells from neoplastic transformation. Moreover, human evolution of what appears to be the longest mammalian life span may have been integrally dependent upon these processes, and an understanding of these mechanisms seems critical to the discovery of methods to improve longevity and limit toxicity from a number of environmental exposures.
KeywordsCaloric Restriction Brown Norway Increase Life Span Aberrant Gene Expression Peromyscus Leucopus
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