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Treatment of the Male

  • Chapter
Infertility

  • 112 Accesses

Abstract

There is a great deal of pessimism concerning the potential for significant therapy in the male. The reason, I believe, is that therapy in the past has often been limited to the male with marked oligospermia (i.e., sperm count less than 20 million/ml). At these low levels the condition is usually irreversible. Influenced by MacLeod and Gold’s report,1 therapists considered the subfertile male, with 20 to 40 million/ml, as “normal” or “fertile,” and treatment was often withheld from this group. If, however, one accepts the concept of the couple as a unit, and that a sperm count of 20 to 40 million/ml cc represents subfertility, treatment of this subfertile male could be meaningful as far as the couple is concerned. Ironically, this is the group of males for whom the most can be done, and yet who often go without treatment.

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References

  1. MacLeod J, Gold RA: The male factor in fertility and infertility. J Urol 66:436, 1951

    PubMed  CAS  Google Scholar 

  2. Nelson CMK, Bunge RG: Semen analysis: Evidence for changing parameters of male fertility potential. Fertil Steril 25:503, 1974

    PubMed  CAS  Google Scholar 

  3. Rehan NE, Sobrero AH, Fertig JW: The semen of fertile men: Statistical analysis of 1300 men. Fertil Steril 26:492, 1975

    PubMed  CAS  Google Scholar 

  4. Heller G, Nelson WO, Hill IB, et al: Improvement in spermatogenesis following depression of the human tests with testosterone. Fertil Steril 1:415, 1950

    PubMed  CAS  Google Scholar 

  5. Rowley MJ, Heller CG: The testosterone rebound phenomenon in the treatment of male infertility. Fertil Steril 23:498, 1972

    PubMed  CAS  Google Scholar 

  6. Lamensdorf H, Compere D, Begley G: Testosterone rebound therapy in the treatment of male infertility. Fertil Steril 26:469, 1975

    PubMed  CAS  Google Scholar 

  7. Rowley MJ, Heller CG: Inhibition and stimulation of human spermatogenesis. In Behrman SJ, Kistner RW (eds): Progress in Infertility, 2nd ed. Boston, Little Brown, 1975, p 719

    Google Scholar 

  8. Brown S: The effect of orally administered androgens on sperm motility. Fertil Steril 26:305, 1975

    PubMed  CAS  Google Scholar 

  9. Mellinger R, Thompson R: The effect of clomiphene citrate in male infertility. Fertil Steril 17:94, 1966

    PubMed  CAS  Google Scholar 

  10. Wieland R, Ansari A, Klein D, et al: Idiopathic oligospermia: Control observations and response to cisclomiphene. Fertil Steril 23:471, 1972

    PubMed  CAS  Google Scholar 

  11. Schellen T, Beck J: Use of clomiphene treatment for male sterility. Fertil Steril 25:407, 1974

    PubMed  CAS  Google Scholar 

  12. Paulson DF, Wacksman J: Clomiphene citrate in the management of male infertility. J Urol 115:73, 1976

    PubMed  CAS  Google Scholar 

  13. Heller CG, Rowley MJ, Heller GV: Clomiphene citrate: A correlation of its effect on sperm concentration and morphology; Total gonadotropins, ICSH, estrogen and testosterone excretion and testicular morphology in normal men. J Clin Endocronol Metab 29:638, 1969

    Article  CAS  Google Scholar 

  14. Charny CW: Clomiphene therapy in male infertility: A negative report. Fertil Steril 32:551, 1979

    PubMed  CAS  Google Scholar 

  15. Newton R, Solinfeld JS, Schiff I: Clomiphene treatment of infertile men: Failure of response with idiopathic oligospermia. Fertil Steril 34:399, 1980

    PubMed  CAS  Google Scholar 

  16. Sokol RZ, Steiner BS, Bustillo M, Peterson G, Swerdloff RS: A controlled comparison of the efficacy of clomiphene citrate on male infertility. Fertil Steril 49:865, 1988

    PubMed  CAS  Google Scholar 

  17. Turner H, Zanartu J, Nelson W: Effect of chorionic gonadotropin therapy on fertility in males with scrotal tests. Fertil Steril 15:24, 1964

    PubMed  CAS  Google Scholar 

  18. Dorner TG, Moch G, Zabel H: The “over production effect” of these tests after cessation of human chorionic gonadotropin administration in men with oligoasthenospermia. Fertil Steril 11:457, 1960

    Google Scholar 

  19. Glass S, Holland H: Treatment of oligospermia with large doses of human chorionic gonadotropin: A preliminary report. Fertil Steril 14:500, 1963

    PubMed  CAS  Google Scholar 

  20. Futterweit W, Sobrero AJ: Treatment of normogonadotropic oligospermia with large doses of chorionic gonadotropin. Fertil Steril 19:971, 1968

    PubMed  CAS  Google Scholar 

  21. Rowley MJ, Heller CG: Inhibition and stimulation of human spermatogenesis. In Behrman SJ, Kistner RW (eds): Progress in Infertility, 2nd ed. Boston, Little, Brown, 1975, p 719

    Google Scholar 

  22. MacLeod J, Pazianos A, Ray B: The restoration of human spermatogenesis and of the reproductive tract with urinary gonadotropins following hypophysectomy. Fertil Steril 17:7, 1966

    PubMed  CAS  Google Scholar 

  23. Lytton B, Mroueh A: Treatment of oligospermia with urinary human menopausal gonadotropin: A preliminary report. Fertil Steril 17:696, 1966

    PubMed  CAS  Google Scholar 

  24. Polishuk W, Palti Z, Laufer A: Treatment of defective spermatogenesis with human gonadotropins. Fertil Steril 18:127, 1967

    PubMed  CAS  Google Scholar 

  25. Danezis J, Batrinos M: The effect of human postmenopausal gonadotropins on infertile men with severe oligospermia. Fertil Steril 18:788, 1967

    PubMed  CAS  Google Scholar 

  26. Mroueh A, Lytton B, Kase N: Effects of human chorionic gonadotropin and human menopausal gonadotropin (Pergonal) in males with oligospermia. J Clin Endocrinol Metab 27:53, 1967

    Article  PubMed  CAS  Google Scholar 

  27. Schwartzstein L: Human menopausal gonadotropins in treatment of patients with oligospermia. Fertil Steril 25:813, 1974

    Google Scholar 

  28. Zarate A, Valdes-Vallina F, Gonzalez A, et al: Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. Fertil Steril 24:485, 1973

    PubMed  CAS  Google Scholar 

  29. Schwartzstein L, Aparicio NJ, Turner D, et al: Use of synthetic luteinizing hormone-releasing hormone in treatment of Oligospermic men: A preliminary report. Fertil Steril 26:331, 1975

    Google Scholar 

  30. Shargle AA: Treatment of idiopathic hypogonadism in men with luteinizing hormone-releasing hormone: A comparison of treatment with daily injections and with a pulsatile infusion pump. Fertil Steril 47:492, 1987

    Google Scholar 

  31. Stewart BH: Infertility in the male: Method of Bruce H. Stewart. In Conn HF (ed): Current Therapy. Philadelphia, WB Saunders, 1971, p 442

    Google Scholar 

  32. Mancini R, Lavieri J, Muller F, et al: Effect of prednisone upon normal and pathologic human spermatogenesis. Fertil Steril 17:500, 1966

    PubMed  CAS  Google Scholar 

  33. Taymor ML, Selenkow HA: Clinical experience with L-triiodothyronine in male infertility. Fertil Steril 9:560, 1958

    PubMed  CAS  Google Scholar 

  34. MacLeod S, Hotchkiss RS: The effect of hyperpyrexia upon spermatozoa counts in man. Endocrinology 28:760, 1941

    Article  Google Scholar 

  35. Lynch R, Lewis-Jones DI, Machlin DG, Desmond AD: Improved seminal characteristics in infertile men after a conservative treatment regimen based on the avoidance of testicular hypothermic. Fertil Steril 46:476, 1986

    PubMed  CAS  Google Scholar 

  36. Zorgniotti AW, Cohen MS, Sealfon AI: Chronic scrotal hypothermia: Results in 90 infertile couples. J Urol 135:944, 1980

    Google Scholar 

  37. Haesungeharern A, Chulavatnatol M: Stimulation of human spermatozoal motility by caffemc Fertil Steril 24:662, 1973

    Google Scholar 

  38. Schoenfeld C, Amelar RD, Dubin C: Stimulation of ejaculated human spermatozoa by caffeine. Fertil Steril 24:662, 1973

    Google Scholar 

  39. Dougherty KA, Cockett ATK, Urry RI: Caffeine theophylline and human sperm motility. Fertil Steril 27:541, 1976

    PubMed  CAS  Google Scholar 

  40. Davidson HA: Testicular temperature and varicocele. Practitioner 173:703, 1955

    Google Scholar 

  41. Hanely HG: The surgery of male subfertility. Ann R Coll Surg Engl 17:159, 1955

    Google Scholar 

  42. Charny C: Effect of varicocele on fertility: Results of varicocelectomy. Fertil Steril 13:47, 1962

    PubMed  CAS  Google Scholar 

  43. Dubin L, Amelar R: Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertil Steril 21:606, 1970

    PubMed  CAS  Google Scholar 

  44. Dubin L, Amelar R: Varicocelectomy as therapy in male infertility: A study of 504 cases. Fertil Steril 26:217, 1975

    PubMed  CAS  Google Scholar 

  45. Mehan D: Results of ligation of internal spermatic vein in the treatment of infertility in azoospermic patients. Fertil Steril 27:110, 1976

    PubMed  CAS  Google Scholar 

  46. Brown JS: Varicocelectomy in the subfertile male: A ten-year experience with 295 cases. Fertil Steril 27:1046, 1976

    PubMed  CAS  Google Scholar 

  47. Palti Z, Kedar S, Polishuk W: Ligature of left spermatic vein in the treatment of oligospermia. Fertil Steril 19:631, 1968

    PubMed  CAS  Google Scholar 

  48. Fogh-Anderson P, Nielson NC, Rebbe H, et al: The effects on fertility of litigation of external spermatic vein in men without clinical signs of varicocele. Acta Obstet Gynecol Scand 54:29, 1975

    Article  Google Scholar 

  49. Vermeulen A, Vanlewegle M: Improved fertility after varicocele correction: Fact or fiction. Fertil Steril 42:249, 1984

    PubMed  CAS  Google Scholar 

  50. Winer JH: The surgery of male infertility. In Behrman S J, Kistner RW (eds): Progress in Infertility, 2nd ed. Boston, Little, Brown, 1975, p 729

    Google Scholar 

  51. Amelar R: Infertility in Men, Philadelphia, FA Davis, 1966, p 124

    Google Scholar 

  52. Kar J, Phadke A: Vaso-epididymal anastomasis. Fertil Steril 26:743, 1975

    PubMed  CAS  Google Scholar 

  53. Pardanani DS, Kothari MS, Pradhan SA, Mahendrakar MN: Surgical restoration of vas continuity after vasectomy: Further clinical evaluation of a new operation technique. Fertil Steril 25:319, 1974

    PubMed  CAS  Google Scholar 

  54. Amelar RD, Dublin L: Male infertility, current diagnosis and treatment. Urology 1:1, 1973

    Article  PubMed  CAS  Google Scholar 

  55. Amelar RD: Medical management of male infertility. In Crockett ATK, Urry RL (eds): Male Infertility. New York, Grune and Stratton, 1976, p 249

    Google Scholar 

  56. Zavos PM, Wilson EA: Retrograde ejaculation: Etiology and treatment via the use of a new non-invasive method. Fertil Steril 42:627, 1984

    PubMed  CAS  Google Scholar 

  57. Arny M, Quaglianello J: Semen quality before and after processing by a swim-up method: Relationship to outcome of intrauterine insemination. Fertil Steril 48:643, 1987

    PubMed  CAS  Google Scholar 

  58. Matson PL, Blackledge DG, Richardson PA, Turner SR, Yovich JM, Yovich JL: The role of gamete intrafallopian transfer (GIFT) on the treatment of Oligospermic infertility. Fertil Steril 46:608, 1987

    Google Scholar 

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Authors and Affiliations

  1. Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Melvin L. Taymor M.D. (Professor of Life Sciences and Technology and Clinical Professor Emeritus of Obstetrics and Gynecology)

  2. Harvard Medical School, Boston, Massachusetts, USA

    Melvin L. Taymor M.D. (Professor of Life Sciences and Technology and Clinical Professor Emeritus of Obstetrics and Gynecology)

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  1. Melvin L. Taymor M.D.
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© 1990 Plenum Publishing Corporation

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Taymor, M.L. (1990). Treatment of the Male. In: Infertility. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0627-6_21

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  • DOI: https://doi.org/10.1007/978-1-4613-0627-6_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7899-3

  • Online ISBN: 978-1-4613-0627-6

  • eBook Packages: Springer Book Archive

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