Metabolism of Recombinant Human Erythropoietin in the Rat
Erythropoietin is the only hematopoietic growth factor which behaves like a hormone. Produced primarily in the kidneys and to a small extent in the liver, erythropoietin interacts with primitive erythroid progenitor cells in the bone marrow. Under normal circumstances, the plasma concentracentration of erythropoietin is maintained within narrow limits but is subject to change according to the adequacy of tissue oxygenation. Thus, tissue hypoxia stimulates erythropoietin production while a surfeit of oxygen suppresses it. Erythropoietin, however, is never absent from the plasma since it is an obligatory growth factor for erythroid progenitor cells1.
KeywordsSialic Acid Plasma Clearance Dextran Sulfate Recombinant Human Erythropoietin Sialic Acid Residue
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