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Trophoblast Invasion and Endometrial Receptivity pp 115–138Cite as

Adhesive Interactions of Murine and Human Trophoblast Cells

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Part of the book series: Trophoblast Research ((TR,volume 4))

Abstract

Successful implantation of the embryo requires a complex and ordered series of adhesive interactions occurring between the trophoblast cells of the blastocyst and the uterus. First, the blastocyst hatches from the acellular zona pellucida and attaches to the uterine epithelium. These initial adhesive interactions are probably transient since in mice and in humans the cells of the trophoblast outgrowth are also invasive. As a result, these cells rapidly penetrate the uterine epithelium and its associated basement membrane, then invade the endometrium where they contact decidual cells, each of which is surrounded by a specialized basement membrane collar (Wewer et al., 1985, 1986). Invasion stops once the trophoblast cells have penetrated the uterine arterioles and tapped the maternal blood supply (Ramsey et al, 1976). The result is formation of the hemochorial placenta, in which blood from the maternal circulation constantly bathes the fetal chorionic villi. Thus, both cell-cell and cell-matrix interactions are important in the adhesive interactions that occur during placental development.

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Author information

Author notes

  1. Susan J. Fisher

    Present address: University of California-San Francisco, HSW 604, Box 0512, San Francisco, California, 94143-0512, USA

Authors and Affiliations

  1. Division of Oral Biology, School of Dentistry, University of California, San Francisco, California, 94143, USA

    Susan J. Fisher & Lynn Hartman

  2. Division of Periodontology, School of Dentistry, University of California, San Francisco, California, 94143, USA

    Eileen Crowley & Caroline Damsky

  3. Department of Anatomy, School of Medicine, University of California, San Francisco, California, 94143, USA

    Susan J. Fisher, Ann Sutherland, Lenny Moss, Patricia Calarco & Caroline Damsky

  4. Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, California, 94143, USA

    Susan J. Fisher

  5. Joint Program in Neonatology, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Merton Bernfield

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  1. Susan J. Fisher
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Editor information

Editors and Affiliations

  1. University Clinics, Essen, Federal Republic of Germany

    Hans-Werner Denker

  2. St. Mary’s Hospital, Manchester, UK

    John D. Aplin

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© 1990 University of Rochester

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Fisher, S.J. et al. (1990). Adhesive Interactions of Murine and Human Trophoblast Cells. In: Denker, HW., Aplin, J.D. (eds) Trophoblast Invasion and Endometrial Receptivity. Trophoblast Research, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0615-3_6

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  • DOI: https://doi.org/10.1007/978-1-4613-0615-3_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7893-1

  • Online ISBN: 978-1-4613-0615-3

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