Evolutionary Meanings of the Primary and Secondary Structures of the “UR-RNA”, A Primitive Possibly Self-Replicating Ribo-Organism Commonly Ancestral to tRNAs, 5S-rRNA and Virusoids

  • Koji Ohnishi


Recent advances in the study of catalytic RNAs have allowed us to consider that the first self-replicating organism was almost undoubtedly an RNA without protein-encoding informations (Watson et al., 1987; Orgel, 1987; Schwartz et al., 1987; Cech, 1989a; Joice, 1989). The class I intron of Tetrahymena pre-rRNA, virusoids, viroids, RNA portion (M1 RNA) of ribonuclease P and the delta element of hepatitis B virus are representatives of these catalytic RNAs (See reviews in Cech, 1989b and Diener, 1987a).


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  1. Bloch, D., McArthur, B., Widdowson, R., Spector, D., Guimaraes, R.C. and Smith, J., 1983. J. Mol. Evol., 19: 420–428. (See also 1984. Origins Life, 14: 571–578, by the same authors.)Google Scholar
  2. Bloch, D. and Staves, M., 1986. Origins Life, 16: 309–310.CrossRefGoogle Scholar
  3. Branch, A.D., Benefeld, B.J. and Robertson, H.D., 1988. Proc. Nat. Acad. Sci. USA, 85: 9128–9132.PubMedCrossRefGoogle Scholar
  4. Branch, A.D. and Robertson, H.D., 1984. Science, 223: 450–455.PubMedCrossRefGoogle Scholar
  5. Branch, A.D., Robertson, H.D., and Dickson, E., 1981. Proc. Nat. Acad. Sci. USA, 78: 6381–6385.PubMedCrossRefGoogle Scholar
  6. Brosius, J., Dull, T.J. and Sleeter, D.D., 1981. J. Mol. Biol., 148:107–127.PubMedCrossRefGoogle Scholar
  7. Brune, M., Schumann, R. and Wittinghofer, F., 1985. Nucleic Acid Res., 13: 7139–7151.PubMedCrossRefGoogle Scholar
  8. Cech, T.R., 1989a. Nature (Lond.), 336: 507–508.CrossRefGoogle Scholar
  9. Cech, T.R. (ed.), 1989b. “Molecular Biology of RNA”, A. R. Liss, New York.Google Scholar
  10. Chen, R., 1976. Hoppe-Seyler’s Z. Physiol. Chem., 357: 873–886.PubMedCrossRefGoogle Scholar
  11. Diener, T.O. (ed.), 1987a. “The Viroids”, Plenum, New York.Google Scholar
  12. Diener, 1987b. In: Diener (ed., 1987a), pp.1–5.Google Scholar
  13. Diener, 1987c. In: Diener (ed., 1987a)., pp.9–35.Google Scholar
  14. Dawkins, R., 1976. “The Selfish Gene”, Oxford University Press, Oxford.Google Scholar
  15. Dawkins, R., 1982. “The Extended Phenotype”, Oxford University Press, Oxford.Google Scholar
  16. Dawkins, R., 1986. “The Blind Watchmaker”, Longman, Harlow, Essex.Google Scholar
  17. De Jong, W.W., Gleaves, J.T. and Boulter, D., 1977. J. Mol. Evol., 10:123–135.CrossRefGoogle Scholar
  18. De Jong, W.W., Zweers, A., Joysey, K.A., Gleaves, J.T. and Boulter, D., 1985. In: “The Evolution and Ecology of Armadillos, Sloths, and Vermilinguas”, ed. by G. G. Montgomery, pp. 65–76, Smithsonian Institution Press, Washington and London.Google Scholar
  19. Doolittle, W.F. and Sapienza, C., 1980. Nature (Lond.), 284: 601–603.CrossRefGoogle Scholar
  20. Eigen M., 1978. Naturwissenschften, 65: 341–369.CrossRefGoogle Scholar
  21. Erdmann, V. and Wolters, J., 1986. Nucleic Acids Res., 14(Suppl.): r1-r59.PubMedGoogle Scholar
  22. Evrard, J.-J., et al., 1988. Gene, 71: 115–122.PubMedCrossRefGoogle Scholar
  23. Forster, A.C. and Symons, R.H., 1987a. Cell, 49: 211–220.CrossRefGoogle Scholar
  24. Forster, A.C. and Symons, R.H., 1987b. Cell, 50: 9–16.CrossRefGoogle Scholar
  25. Forster, A.C., Jeffries, A.C., Shelton, C.C. and Symons, R.H., 1987. Cold Spring Harbor Symp. Quant. Biol., 52: 249–259.PubMedGoogle Scholar
  26. Francki, R.I.B., In: Diener (ed., 1987a), pp. 205–218.Google Scholar
  27. Hamilton, W.D., 1964a. J. Theoret. Biol., 7: 1–16.CrossRefGoogle Scholar
  28. Hamilton, W.D., 1964b. J. Theoret. Biol., 7: 17–52.CrossRefGoogle Scholar
  29. Hartley, R.W. and Barker, E.A., 1972. Nature, New Biol., 235: 15–16.Google Scholar
  30. Hansen, F.G., Hansen, E.B. and Atlung, T., 1985. Gene 38: 85–93.PubMedCrossRefGoogle Scholar
  31. Haseloff, J. and Symons, R.H., 1981. Nucleic Acids Res., 9: 2741–2752.PubMedCrossRefGoogle Scholar
  32. Hennig, W., 1966. “Phylogenetic Systematics”, University of Illinois Press [Transi. by D. Dwight and R. Zangerl from: Hennig’s “Grundzuege einer Theorie der phylogenetischen Systematik” (1950)]Google Scholar
  33. Hennig, W., 1965. Ann. Rev. Entomol., 10: 97–116.CrossRefGoogle Scholar
  34. Hirsch, D., 1971. J. Mol. Biol., 58: 439–458.CrossRefGoogle Scholar
  35. Joice, G.F., 1989. In: Cech (ed., 1989b), pp. 361–371.Google Scholar
  36. Kanaya, S. and Crouch, R.J., 1983. J. Biol. Chem., 258: 1276–1281.PubMedGoogle Scholar
  37. Keese, P. and Symons, R.H., 1987. In: Diener (ed., 1987a), pp. 37–62.Google Scholar
  38. Keese, P., Bruening, G. and Symons, R.H., 1983. FEBS Letter, 159: 185–190.CrossRefGoogle Scholar
  39. Koestler, A., 1978. “Janus A summing up”, Huchinson, London.Google Scholar
  40. Lacey, J.C., Jr., Staves, M.P., and Bloch, D.P., 1986. Origins Life, 16: 525–526.CrossRefGoogle Scholar
  41. Margulis, L., 1981. “Symbiosis and Cell Evolution”, McGraw-Hill, New York.Google Scholar
  42. Marotta, C.A., Varricchio, F., Smith, I. and Weissman, S.M., 1976. J. Biol. Chem., 251: 3122–3127.PubMedGoogle Scholar
  43. Matsukage, A. et al., 1987., J. Biol. Chem., 262: 8960–8962.PubMedGoogle Scholar
  44. Mayer, E., 1969. “Principles of Systematic Zoology”, McGraw-Hill, New York.Google Scholar
  45. Moore, G.W. and Goodman, M, 1977. J. Mol. Evol., 9: 121–130.PubMedCrossRefGoogle Scholar
  46. Murgora, E.J., Goeringer, H.U., Dahlberg, A.E. and Hijazi, K.A., 1989. In: Cech (ed.), pp. 221–229.Google Scholar
  47. Nazarea, A.D., Bloch, D.P. and Semrau, A.C., 1985. Proc. Nat. Acad. Sci. USA, 82: 5337–5341.PubMedCrossRefGoogle Scholar
  48. Nairn, C.J. and Orgel, L.E. and Crick, R.J., 1988. J. Mol. Evol., 27: 133–141.PubMedCrossRefGoogle Scholar
  49. F.H.C., 1980. Nature (Lond.), 284:604–607.CrossRefGoogle Scholar
  50. Ohnishi, K., 1984a. Origins Life, 14: 707–715.CrossRefGoogle Scholar
  51. Ohnishi, K., 1984b. Origins Life, 14: 716–724.Google Scholar
  52. Ohnishi, K., 1986a. Origins Life, 16: 247–248.CrossRefGoogle Scholar
  53. Ohnishi, K., 1986b. Nucleic Acids Res., Symp. Ser., No.17, 127–130.Google Scholar
  54. Ohnishi, K., 1986c. Origins Life, 16: 326–227.CrossRefGoogle Scholar
  55. Ohnishi, K., 1987. Viva Origino, 16: 69–85.Google Scholar
  56. Ohnishi, K., 1988. Viva Origino, 16: 230–232.Google Scholar
  57. Ohnishi, K., 1988b. Nucleic Acids Res., Symp. Ser., No.20, 97–98.Google Scholar
  58. Ohnishi, K., 1989a. Origins Life, 19(3/4): in press. [two pages with Figures and a Table].Google Scholar
  59. Ohnishi, K., 1989b. In: “Endocytobiology IV. Proceedings of the 4th International Colloquium on Endocytobiology and Symbiosis”, in press.Google Scholar
  60. Ohnishi, K., 1989c. Origins Life, 19(3/4): in press.[two pages with a Figure of aa sequence alignment].Google Scholar
  61. Ohnishi, K., 1989d. in preparation.Google Scholar
  62. Ohnishi, K., 1989e. Origins Life, 19(3/4): in press. [two pages with a Figure of aa sequence alignment].Google Scholar
  63. Ollis, D.L., Brick, P., Hamlin, R., Xuong, N.G. and Steiz, T.A., 1985. Nature (Lond.), 313: 818–819.CrossRefGoogle Scholar
  64. Orgel, L.E., 1987. Cold Spring Harbor Symp. Quant. Biol., 52: 9–16.PubMedGoogle Scholar
  65. Orgel, L.E. and Crick, F.H.C., 1980. Nature (Lond.), 284: 604–607.CrossRefGoogle Scholar
  66. Osorio-Almeida, M., Guillemaut, P., Keith, G., Canaday, J. and Well, J.H., 1980. Biochem. Biophys. Res. Comm., 92: 102–108.PubMedCrossRefGoogle Scholar
  67. Reed, R.E., Bauer, M.F., Guerrier-Takada, C., Donis-Keller, H. and Altman, S., 1982. Cell 30: 627–636.PubMedCrossRefGoogle Scholar
  68. Sakamoto, H., Kimura, N. and Shimura, Y., 1983. Proc. Nat. Acad. Sci. USA, 80: 6187–6191, 1983Google Scholar
  69. Schwartz, A.Z., Visscher, J., van der Woerd, R. and Baker, C.G., 1987. Cold Spring Harbor Symp. Quant. Biol., 52: 37–51.PubMedGoogle Scholar
  70. Shiraishi, H. and Shimura, Y., 1988. EMBO J., 7: 3817–3821.PubMedGoogle Scholar
  71. Spinzl, M., Moll, J., Meissner, F. and Hartman, T., 1985. Nucleic Acids Res., 13(Suppl.): r1-r49.Google Scholar
  72. Vogel, H., 1978. J. Mol. Evol., 10: 339–348.PubMedCrossRefGoogle Scholar
  73. Watson, J.D., Hopkins, N.H., Roberts, J.W., Steitz, J.A. and Weiner, A.M., 1987. “Molecular Biology of the Gene. 4th ed.”, Benjamin/Cummings, Menlo Park, California.Google Scholar
  74. Wheeler, W.M., 1923. “Social Life among the Insects”, Harcourt, Brace & World, New York.Google Scholar
  75. Wilson, E.O., 1975. “Sociobiology: The New Synthesis”, Belknap Press of Harvard University Press, Cambridge, Massachusetts.Google Scholar
  76. Yaniv, M. and Barell, B.G., 1971. Nature (Load.), 233: 113–114.Google Scholar
  77. Yarus, M. and Barell, B.G., 1971. Biochem. Biophys. Res. Comm., 43: 729–734.PubMedCrossRefGoogle Scholar
  78. Yong, R.A., 1979. J. Biol. Chem., 254: 12725–12731.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Koji Ohnishi
    • 1
  1. 1.Department of Biology, Faculty of ScienceNiigata UniversityNiigataJapan

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