Effects of Latex and Different Doses of Silica on Behavior of Iron Particles in Rabbit Lungs
Silica is known to have a fibrogenic effect on pulmonary tissue and give rise to silicosis. Frequent complications of pulmonary infection suggest the disturbed clearance in the silicotic lung. Early studies on the pathogenesis of silicosis suggested that the basic lesion was to macrophages. Silica has been shown to be toxic for macrophages.
KeywordsRubber Hematoxylin Eosin Silicosis
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- 1).Gehr, P., Brain, J.D., Nemoto, I. & Bloom, S.B.: Behavior of magnetic particles in hamster lungs: estimates of clearance and cytoplasmic motility. J Appl Physiol Respirat Environ Exercise Physiol 55: 1196–1202, 1983.Google Scholar
- 3).Brain, J.D., Hu, T., and Bloom, S.B.: Effects of SiO2 and Fe2O3 on macrophage motility and on clearance of magnetic particles from hamster lungs. 5th World Conference on Biomagnetism, 1984.Google Scholar
- 4).Aizawa, Y., Kurihara, M., Hashimoto, K., Maeda, A., Takata, T., Kotani, M., Chiyotani, K. and Yagami, T.:Effect of silica on relaxation and clearance of iron particles in rabbit lungs. Biomagnetism’87 p.374.-377, Tokyo Denki University Press, Tokyo, 1988.Google Scholar