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Effects of Latex and Different Doses of Silica on Behavior of Iron Particles in Rabbit Lungs

  • Yoshiharu Aizawa
  • Tsutomu Takata
  • Kiichiro Hashimoto
  • Mamoru Tominaga
  • Hiroshi Tatsumi
  • Makoto Kotani
  • Keizo Chiyotani

Abstract

Silica is known to have a fibrogenic effect on pulmonary tissue and give rise to silicosis. Frequent complications of pulmonary infection suggest the disturbed clearance in the silicotic lung. Early studies on the pathogenesis of silicosis suggested that the basic lesion was to macrophages. Silica has been shown to be toxic for macrophages.

Keywords

Iron Particle Relaxation Curve Iron Oxide Particle Rabbit Lung Clearance Curve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1).
    Gehr, P., Brain, J.D., Nemoto, I. & Bloom, S.B.: Behavior of magnetic particles in hamster lungs: estimates of clearance and cytoplasmic motility. J Appl Physiol Respirat Environ Exercise Physiol 55: 1196–1202, 1983.Google Scholar
  2. 2).
    Brain, J.D., Bloom, S.B., Valberg, P.A. & Gehr, P.: Correlation between the behavior of magnetic iron oxide particles in the lungs of rabbits and phagocytosis. Exper Lung Res 6: 115–131, 1984.CrossRefGoogle Scholar
  3. 3).
    Brain, J.D., Hu, T., and Bloom, S.B.: Effects of SiO2 and Fe2O3 on macrophage motility and on clearance of magnetic particles from hamster lungs. 5th World Conference on Biomagnetism, 1984.Google Scholar
  4. 4).
    Aizawa, Y., Kurihara, M., Hashimoto, K., Maeda, A., Takata, T., Kotani, M., Chiyotani, K. and Yagami, T.:Effect of silica on relaxation and clearance of iron particles in rabbit lungs. Biomagnetism’87 p.374.-377, Tokyo Denki University Press, Tokyo, 1988.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Yoshiharu Aizawa
    • 1
  • Tsutomu Takata
    • 1
  • Kiichiro Hashimoto
    • 1
  • Mamoru Tominaga
    • 1
  • Hiroshi Tatsumi
    • 1
  • Makoto Kotani
    • 2
  • Keizo Chiyotani
    • 3
  1. 1.Department of Preventive Medicine and Public Health, School of MedicineKitasato UniversityKanagawaJapan
  2. 2.ElectronicsTokyo Denki UniversityTokyoJapan
  3. 3.Rosai Hospital for SilicosisTochigiJapan

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