Relation of Serum Parathyroid Hormone to Cognitive Function in Elderly Females
Senile dementia is one of the serious diseases of the aged. The cause(s) of this disease is unknown, but the role of calcium (Ca) in regulation of the mental state of elderly subjects is receiving increasing attention.1 Chronic nutritional deficiency of Ca has been suggested to induce aberrations in mineral metabolism resulting in the abnormal accumulation of Ca and non-essential trace metals in neurons.2 Possible associations of the well-known Ca-regulating hormones parathyroid hormone (PTH),3–7 calcitonin (CT)8,9 and 1,25-dihydroxyvitamin D [1,25-(0H)2D]10,11 with senile dementia have been reported. However, there have been few precise measurements of Ca and Ca-regulating hormones in elderly subjects with senile dementia. In this study, we measured Ca-related factors in elderly females with and without dementia. Cases of dementia were classified into Alzheimer- and vascular-types on the bases of cognitive function and ischemic score. We found that the circulating level of PTH was significantly elevated in cases of dementia especially of the Alzheimer-type.
KeywordsHPLC Creatinine Dementia Choline Acetyl
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