Abstract
Since Crass and Pang (1) reported coronary vasodilator and positive inotropic effects of parathyroid hormone (PTH), it has become clear that PTH definitely increased the coronary blood flow in dogs and decreased the blood pressure of rats (2-4). We also reported soon after Crass and Pang cardiovascular effects of PTH in the dog (2). However questions relating to those effects of PTH, such as on the species difference, selectivity on vascular muscle or cardiac muscle, cellular mechanisms of action, physiological role or its possible clinical implications are still open for discussion. This paper deals with the analysis of our previous paper (2) with a review of recently published papers.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
M.F. Crass III, P.K.T. Pang, Parathyroid hormone: A coronary artery vasodilator, Science 207: 1087 (1980)
K. Hashimoto, Y. Nakagawa, T. Shibuya, H. Satoh, T. Ushijima, S. Imai, Effects of parathyroid hormone and related polypeptides on the heart and coronary circulation of dogs, J. Cardiovasc. Pharmacol. 3: 668 (1981)
G.A. Nickols, Actions of parathyroid hormone in the cardiovascular system, Blood Vessels 24: 120 (1987)
M.F. Crass III, P.L. Moore, M.L. Strickland, P.K.T. Pang, M.S. Citak, Cardiovascular responses to parathyroid hormone, Am. J. Physiol. 249: E187, (1985)
P. Trinder, Colorimetrie micro-determination of calcium in serum, Analyst 85: 889 (1960)
J-L. Delsal, H. Manhouri, Etude comparative des dosages colorimetriques du phosphore. IV. Dosage de 1–orthophosphate en presence d’esters phosphoriques (nouvelles methodes), Bull Soc Chim Biol 40: 1623 (1958)
R. Nakamura, H. Sokabe, T. Kimura, S. Sakakibara, Action of fragments of human parathyroid hormone on blood pressure in rats, Endocrinol. Japon. 28: 547 (1981)
P.K.T. Pang, T. E. Tenner Jr, Y. A. Yee, M. Yang, H.F. Janssen, Hypotensive action of parathyroid hormone preparations on rats and dogs, Proc Natl Acad Sci USA 77: 675 (1980)
Y. Katano, K. Takeda, T. Otorii, D. Horii, S. Imai, Effects of dilazep, dipyridamole and hexobendine on the heart and coronary circulation, Fol. Pharmacol Jpn 70: 305 (1974)
E. Bogin, S.G. Massry, I. Harary, Effect of parathyroid hormone on rat heart cells, J. Clin. Invest. 67: 1215 (1981)
M. Feola, M.F. Crass III, Parathyroid hormone reduces acute ischemic injury of the myocardium, Surg. Gyne. Obst. 163: 523 (1986)
K. Hashimoto, H. Mitsuhashi, T. Nakamura, K. Akiyama, Antiarrhythmic effects of possible anti-ischemic drugs, in “Proc. 4th Cong. Hung. Pharmacol. Soc. Budapest 1985 Vol. 1. Sec. 1. Pharmacological protection of the myocardium”, L. Szekeres, and J.Gy. Papp, ed., Akademiai Kiado, Budapest (1985)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Hashimoto, K. (1989). Coronary Vasodilatory and Cardiotonic Effects of Parathyroid Hormone in the Dog. In: Massry, S.G., Fujita, T. (eds) New Actions of Parathyroid Hormone. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0567-5_16
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0567-5_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7870-2
Online ISBN: 978-1-4613-0567-5
eBook Packages: Springer Book Archive