Abstract
Hypercalcemia is frequently a serious complication of malignancy. Since in certain patients this condition resembles hyperparathyroidism, a PTH-like factor secreted by the tumor was implicated in this syndrome. Indeed, it was found that several tumors produce a peptide which has PTH-like activity: it stimulates renal and bone adenylate cyclase (Rodan et al., 1983; Stewart et al., 1983), produces bone resorptionin vitro and inhibits phosphate uptake in kidney cells (Strewler et al., 1987). Most recently several tumor-derived peptides were partially sequenced and were found to have sequence similarity to PTH (Moseley et al., 1987; Stewart et al., 1987; Strewart et al., 1987). A complementary DNA sequence cloned from a lung carcinoma cell line (BEN) confirmed the similarity of the deduced N-terminal amino acid sequence to that of PTH, and showed very little similarity to the rest of the molecule (Suva et al., 1987).
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© 1989 Plenum Press, New York
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Rodan, G.A., Thiede, M., Thompson, D.D., Noda, M., Rodan, S.B., Rosenblatt, M. (1989). PTH-Like Tumor Hypercalcemia Factor. In: Massry, S.G., Fujita, T. (eds) New Actions of Parathyroid Hormone. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0567-5_12
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DOI: https://doi.org/10.1007/978-1-4613-0567-5_12
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