The Role of Covalent and Non-Covalent Mechanisms in Insulin Receptor Action

  • Paul L. Rothenberg
  • C. Ronald Kahn
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Diminished cellular responsiveness to the metabolic and growth promoting effects of insulin occurs in several pathophysiological conditions - - most commonly in insulin and non-insulin dependent diabetes mellitus, but also in obesity, uremia, glucocorticoid and growth hormone excess, and in certain rare syndromes such as lipoatrophic diabetes and leprechaunism (Kahn, 1985; Reaven, 1988). Although insulin action has been intensively investigated at the physiological and biochemical level for close to half a century, we are only beginning to obtain an in-depth understanding of the molecular mechanism of insulin signal transduction. A complete molecular analysis of this process will be necessary for a rational therapeutic approach to insulin-resistant disease states.


Insulin Receptor Insulin Action Pertussis Toxin Insulin Binding Insulin Signal Transduction 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Paul L. Rothenberg
    • 1
  • C. Ronald Kahn
    • 1
  1. 1.Departments of Pathology and Medicine, Brigham and Women’s HospitalHarvard Medical School and Joslin Diabetes CenterBostonUSA

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