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The Study of Membrane Electrofusion and Electroporation Mechanisms

  • Arthur E. Sowers

Abstract

Electrofusion, the induction of membrane fusion with an electric field pulse, was reported independently in four laboratories (Neumann et al., 1980; Senda et al., 1979; Teissie et al., 1982; Zimmermann et al., 1981). Although most papers which report on the use of electrofusion have genetic manipulation purposes, electrofusion has been shown to have special advantages for producing monoclonal antibody-secreting hybridomas (Karsten et al., 1988; Lo and Tsong, 1989; Glassy and Pratt, 1989). Also, as will be explained below, electrofusion is a promising new way to study membrane fusion mechanisms.

Keywords

Electric Pulse Membrane Fusion Electric Field Pulse Fusion Event Erythrocyte Ghost 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Arthur E. Sowers
    • 1
  1. 1.The Jerome H. Holland LaboratoryAmerican Red CrossRockvilleUSA

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