Metalloforms of Metallothionein Induced by Parenteral Copper: The Influence of Route of Administration
Previous results regarding the two metalloforms of MT which accumulate in chick liver following the parenteral administration (ip) of copper were discussed. One metalloform, which is exclusively zinc, was suggested to reflect the marked accumulation of hepatic zinc following copper injection. The present report shows that there is a marked difference in hepatic zinc accumulation if copper is administered iv. Under these conditions there is virtually no change in hepatic zinc and thus MT produced under these conditions appears to contain only copper. We suggest the the changes in zinc metabolism as effected by copper when given intraperitoneally reflect a secondary response analogous to that observed when iron is similarly administered.
KeywordsZinc Metabolism Parenteral Iron Hepatic Copper Parenteral Copper Cupric Acetate
Unable to display preview. Download preview PDF.
- McCormick, C.C. (1987) Iron-induced accumulation of hepatic metallothionein: The lack of glucocorticoid involvement. Proc. Soc. Exp. Biol. Med. 185:143.Google Scholar
- McCormick, C.C. (1986) Iron-induced accumulation of hepatic zinc metallothionein: A marked diminution by short-term dietary zinc depletion. Fed. Proc. 45:1085.Google Scholar
- McCormick, C.C., Lin, L-Y. (1988) The occurrence of Zn7 and Zn, Cu metallothionein in liver of copper-loaded chicks. Proc. 6th International Symposium on Trace Element Metabolism in Man and Animals. ‘In Press’.Google Scholar
- McCormick, CC, Golemboski, K.A., Fleet, J.C, Dietert, R.R. (1988b) Parenteral iron and hepatic metallothionein induction: Characteristics of an associated inflammatory response. FASEB J. 2:A865.Google Scholar