Metalloforms of Metallothionein Induced by Parenteral Copper: The Influence of Route of Administration

  • Charles C. McCormick
  • Lih-Yuan Lin
  • James C. Fleet

Summary

Previous results regarding the two metalloforms of MT which accumulate in chick liver following the parenteral administration (ip) of copper were discussed. One metalloform, which is exclusively zinc, was suggested to reflect the marked accumulation of hepatic zinc following copper injection. The present report shows that there is a marked difference in hepatic zinc accumulation if copper is administered iv. Under these conditions there is virtually no change in hepatic zinc and thus MT produced under these conditions appears to contain only copper. We suggest the the changes in zinc metabolism as effected by copper when given intraperitoneally reflect a secondary response analogous to that observed when iron is similarly administered.

Keywords

Zinc Filtration Cadmium Glucocorticoid Cytosol 

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Charles C. McCormick
    • 1
  • Lih-Yuan Lin
    • 1
  • James C. Fleet
    • 1
  1. 1.Department of Poultry and Avian Sciences and Division of Nutritional SciencesCornell UniversityIthacaUSA

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