Abstract
Recent computer-assisted techniques permit experimental inhaled CO2 stimuli to be precisely shaped, for example to a square wave, while alveolar PO2 (PAO2) is held constant. The respiratory control mechanisms sensitive to CO2 have then been modelled as a two-compartmental first order system, with central and peripheral components, each with a defined time delay (mainly circulatory), time constant and gain1.
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References
J.W. Bellville, B.J. Whipp, R.D. Kaufman, G.D. Swanson, K.A. Agley, and D.M. Wiberg. Central and peripheral loop gain in normal and carotid body-resected subjects, J. Appl. Physiol. 46:843–853 (1979).
A.R.C. Cummin, J. Alison, M.S. Jacobi, V.I. Iyawe, and K.B. Saunders. Ventilatory sensitivity to inhaled carbon dioxide around the control point during exercise. Clin. Sci. 71-17–22 (1986).
M.S. Jacobi, V.I. Iyawe, C.P. Patii, A.R.C. Cummin, and K.B. Saunders. Ventilatory responses to inhaled carbon dioxide at rest and during exercise in man. Clin. Sci. 73:177–182 (1987).
M.S. Jacobi, C.P. Patii, and K.B. Saunders. Ventilatory response to pulses of inhaled CO2 during exercise in man. J. Physiol. (Lond.) 382:51P (1986).
K.B. Saunders, H.N. Bali, and E.R. Carson. A breathing model of the respiratory system: the controlled system. J. Theoret. Biol. 84:135–161 (1980).
N.L. Jones, D.G. Robertson, and J.W. Kane. Difference between endtidal and arterial PCO2 in exercise. J. Appl. Physiol. 47:954–960 (1979).
F.S. Grodins, J. Buell, and A.J. Bart. Mathematical analysis and digital simulation of the respiratory control system. J. Appl. Physiol. 22:260–276 (1967).
N.L. Jones, and E.J.M. Campbell, “Clinical Exercise Testing”. Second Edition. W.B. Saunders, Philadelphia (1981) p 250.
E.S. Petersen, B.J. Whipp, D.B. Drysdale, and D.J.C. Cunningham. In “The regulation of respiration during sleep and anaesthesia”. R.S. Fitzgerald, H. Gautier, and S. Lahiri, eds., Plenum Press, London (1978) pp 335–342.
P.A. McClean, E.A. Phillipson, D. Martinez, and N. Zamel. Single breath of CO2 as a clinical test of the peripheral chemoreflex. J. Appl. Physiol. 64:84–89 (1988).
M.S. Jacobi, C.P. Patil, and K.B. Saunders. Transient, steady state and rebreathing responses to carbon dioxide in man, at rest and during light exercise. J. Physiol. (Lond.) in press, April (1989).
J.P. Miller, D.J.C. Cunningham, B.B. Lloyd, and J.M. Young. The transient respiratory effects in man of sudden changes in alveolar carbon dioxide in hypoxia and high oxygen. Respir. Physiol. 20:17–31 (1974).
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© 1989 Plenum Press, New York
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Saunders, K.B., Patil, C.P., Jacobi, M.S. (1989). Modelling the Ventilatory Response to Pulses of Inhaled Carbon Dioxide in Exercise. In: Swanson, G.D., Grodins, F.S., Hughson, R.L. (eds) Respiratory Control. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0529-3_8
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DOI: https://doi.org/10.1007/978-1-4613-0529-3_8
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