Regulation of Alveolar Ventilation and Arterial Blood Gases During Exercise

  • H. V. Forster
  • L. G. Pan


The mechanism mediating the increase in alveolar ventilation (VA) during exercise remains controversial. Several investigative groups have suggested different theories each supported by impressive evidence. Wasserman et al. (43) have concluded that their studies “strongly point to the existence of a sensitive chemoreceptive mechanism which causes ventilation to increase in proportion to CO2 flow thus maintaining PaCO2 essentially constant.” On the other hand, Kao (30) has concluded, “there is certainly a peripheral neurogenic drive which must be considered as the, or one of the mechanisms of exercise hyperpnea.” Another divergent view is that of Eldridge, et al. (18) who propose that, “neural command signals emanating from the hypothalamus are primarily responsible for the proportional driving of locomotion, respiration, and circulatory adjustments during exercise.” Lastly, in an attempt to reconcile these widely differing viewpoints, Yamamoto (46) hypothesized that there might by “many sufficient mechanisms, each of which in a given, isolated circumstance explains the whole phenomenon. When they act simultaneously, they mask each other.” Therefore, the objective of this report is to review data we have recently obtained on awake humans, ponies, and goats that directly tests each of these hypotheses.


Submaximal Exercise Alveolar Ventilation Central Command Muscular Exercise Dependent Exercise 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • H. V. Forster
    • 1
    • 2
  • L. G. Pan
    • 1
    • 2
  1. 1.Medical College of WisconsinMilwaukeeUSA
  2. 2.Marquette UniversityMilwaukeeUSA

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