Building Dynamic Models of the Control of Breathing During Hypoxia

  • D. S. Ward
  • J. De Goede
  • A. Berkenbosch

Abstract

In studying the control of breathing during manipulations of various stimuli (e.g., CO2, O2 and exercise) frequent use is made of mathematical models [2]. As opposed to the physical sciences, where the models can be derived from fundamental relationships, there is little to guide the model builder in physiological systems. The inevitable model structure inaccuracies will affect the values of the parameters estimated from the data. However, since only rarely is the “true value” of the parameter known, the effects of the model inaccuracy is often not detected.

Keywords

Dioxide Bide 

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References

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • D. S. Ward
    • 1
    • 2
  • J. De Goede
    • 1
    • 2
  • A. Berkenbosch
    • 1
    • 2
  1. 1.Department of PhysiologyUniversity of LeidenNetherlands
  2. 2.Department of AnesthesiologyUCLAUSA

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