Building Dynamic Models of the Control of Breathing During Hypoxia
In studying the control of breathing during manipulations of various stimuli (e.g., CO2, O2 and exercise) frequent use is made of mathematical models . As opposed to the physical sciences, where the models can be derived from fundamental relationships, there is little to guide the model builder in physiological systems. The inevitable model structure inaccuracies will affect the values of the parameters estimated from the data. However, since only rarely is the “true value” of the parameter known, the effects of the model inaccuracy is often not detected.
KeywordsNominal Model Noise Model Ventilatory Response Residual Function Hypoxic Ventilatory Response
Unable to display preview. Download preview PDF.
- J. W. Bellville, D. S. Ward and D. Wiberg. Respiratory System: Modelling and Identification, in: “Systems and Control Encyclopedia: Theory, Technology, Applications.” M. G. Singh, ed., Pergamon Press, Oxford (1988).Google Scholar
- J. Berkenbosch, J. De Goede, C. N. Oliever, J. J. Schuitmaker and E. W. Kruyt. Dynamics of ventilation following sudden isocapnic changes in end-tidal O2 in cats. J. Physiol(Lond) 394:59P, 1987.Google Scholar
- A. Berkenbosch, D. S. Ward, C. N. Oliever, J. De Goede and J. Van Hartevelt. Dynamics of the ventilatory response to step changes in Pco2 of the blood perfusing the brain stem. J. Appl. Physiol. Accepted for publication.Google Scholar
- A. Dahan, I. C. W. Oliever, A. Berkenbosch and J. De Goede. Modelling the dynamic ventilatory response to carbon dioxide in healthly human subjects during normoxia, in: “Respiratory control: Modelling perspective.” G. D. Swanson and F. S. Grodins ed., Plenum, New York (this volume).Google Scholar
- L. Ljung, L. “System Identification: Theory for the user.” Prentice-Hall, Inc., Englewood Cliffs (1987).Google Scholar
- D. S. Ward, J. De Goede, D. Wiberg, A. Berkenbosch and J.W. Bellville. Analysis of a ventilatory noise model in man and cat, in: “Modelling and the control of breathing.” B. J. Whipp and D. M. Wiberg, ed., Elsevier Biomedical, Amsterdam (1983).Google Scholar