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Replication of Adenovirus 2 and Adeno-Associated Virus 2 in Young and Senescent Human Diploid Fibroblasts

  • Piruz Nahreini
  • Arun Srivastava
Conference paper
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Aging has been known since antiquity and, despite being one of mankind’s most inevitable consequences, the molecular basis of aging remains virtually unknown. Although aging research has become a focus of intensive study in recent years and has attracted global attention, there is no unified theory of the origin of aging. The obscure origin of aging has been the subject of a great deal of elegant experimentation and equally good amount of imaginative speculations.

Keywords

Cellular Senescence Senescent Cell Productive Infection Human Diploid Fibroblast Senescent Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bell, E., Marek, L. F., Levinstone, D. S., Merrill, C., Sher, S., Young, I. T., and Eden, M., 1978, Loss of division potential in vitro: Aging or differentiation?, Science 202: 1158–1163.PubMedCrossRefGoogle Scholar
  2. Berk, A. J., 1986, Adenovirus promoters and El A transactivation, Annu. Rev. Genet. 20: 45–79.PubMedCrossRefGoogle Scholar
  3. Berns, K. I., and Bohenzky, R., 1987, Adeno-associated viruses: An update, Adv. Virus Res. 32: 243–307.PubMedCrossRefGoogle Scholar
  4. Bunn, C. L., and Tarrant, G. M., 1980, Limited lifespan in somatic cell hybrids and cybrids, Exp. Cell Res. 127: 385–396.PubMedCrossRefGoogle Scholar
  5. Burmer, G. C., Zeigler, C. J., and Norwood, T. H. 1982, Evidence for endogenous polypeptide- mediated inhibition of cell-cycle transit in human diploid cells, J. Cell Biol. 94: 187–192.PubMedCrossRefGoogle Scholar
  6. Carter, B. J., Koczot, F. J., Garrison, J., Rose, J. A., and Dolin, R., 1973, Separate function provided by adenovirus for adeno-associated virus multiplication, Nature (Lond.) 244: 71–73.Google Scholar
  7. Cheung, A. K. M., Hoggan, M. D., Hauswirth, W. W., and Berns, K. I., 1980, Integration of the adeno-associated virus genome into cellular DNA in latently infected Detroit 6 cells, J. Virol. 33: 739–748.PubMedGoogle Scholar
  8. Cristofalo, V. J., and Sharf, B. B., 1973, Cellular senescence and DNA synthesis, Exp. Cell. Res. 76: 419–427.PubMedCrossRefGoogle Scholar
  9. Dayton, M. A., Nahreini, P., and Srivastava, A., 1989, Augmented nuclease activity during cellular senescence in vitro, J. Cell. Biochem. 39: 75–85.PubMedCrossRefGoogle Scholar
  10. Feinberg, A. P., and Vogelstein, B., 1983, A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity, Anal. Biochem. 132: 6–13.PubMedCrossRefGoogle Scholar
  11. Finch, C. E., and Hayflick, L. E., 1977, Handbook of the Biology of Aging, Van Nostrand-Reinhold, New York, pp. 101–189.Google Scholar
  12. Hayflick, L. E., 1984, Intracellular determinants of cell aging, Mech. Aging Dev. 28: 177 - 185.PubMedCrossRefGoogle Scholar
  13. Hayflick, L. E., and Moorehead, P. S., 196.1, The serial cultivation of human diploid cell strains, Exp. Cell Res. 25: 585–621.Google Scholar
  14. Hodge, L. D., and Scharff, M. D., 1969, Effect of adenovirus on host cell DNA synthesis in synchronized cells, Virology 37: 554–564.PubMedCrossRefGoogle Scholar
  15. Jackson, C. W., Brown, L. K., Somerville, B. C., Lyles, S. A., and Look, A. T., 1984, Two-color flow cytometric measurement of DNA distribution of rat megakaryocytes in unfixed, ultrafractionated marrow cell suspensions, Blood 63: 768–772.PubMedGoogle Scholar
  16. Laughlin, C. A., Tratshin, J.-D., Coon, H., and Carter, B. J., 1983, Cloning of infectious adeno- associated virus genomes in bacterial plasmids, Gene 23: 65–73.PubMedCrossRefGoogle Scholar
  17. Laughlin, C. A., Cardellichio, C. B., and Coon, H. C., 1986, Latent infection of KB cells with adeno-associated virus type 2, J. Virol. 60: 515–524.PubMedGoogle Scholar
  18. Lavery, D., Fu, S. M., Lufkin, T., and Chen-Kiang, S., 1987, Productive infection of cultured human lymphoid cells by adenovirus, J. Virol. 61: 1466–1472.PubMedGoogle Scholar
  19. Ledinko, N., 1967, Stimulation of DNA synthesis and thymidine kinase activity in human embryonic kidney cells infected by adenovirus 2 or 12. Cancer Res. 27: 1459–1469.PubMedGoogle Scholar
  20. Ledinko, N., 1968, Enhanced deoxyribonucleic acid polymerase activity in human embryonic kidney cultures infected with adenovirus 2 or 12, J. Virol. 2: 89–98.PubMedCrossRefGoogle Scholar
  21. Liu, H. T., Baserga, R., and Mercer, W. E., 1985, Adenovirus type 2 activates cell cycle-dependent genes that are a subset of those activated by serum, Mol. Cell. Biol. 5: 2936–2942.PubMedGoogle Scholar
  22. Macieira-Coelho, A., 1984, Genome reorganization during cellular senescence, Mech. Aging Dev. 27: 257–262.PubMedCrossRefGoogle Scholar
  23. Nahreini, P., and Srivastava, A., 1989, Rescue and replication of the adeno-associated virus genome in mortal and immortal human cells, Intervirology. 30: 74–85.PubMedGoogle Scholar
  24. Olashaw, N. E., Kress, E. D., and Cristofalo, V. J., 1983, Thymidine triphosphate synthesis in senescent WI-38 cells, Exp. Cell Res. 149: 547–554.PubMedCrossRefGoogle Scholar
  25. Orgel, L. E., 1963, The maintenance of the accuracy of protein synthesis and its relevance to aging, Proc. Natl. Acad. Sci. USA 49: 517–521.PubMedCrossRefGoogle Scholar
  26. Ostrove, J. M., and Berns, K. I., 1980, Adenovirus early region lb gene function required for rescue of latent adeno-associated virus, Virology 104: 502–505.PubMedCrossRefGoogle Scholar
  27. Pina, M., and Green, M., 1969, Biochemical studies on adenovirus multiplication. XIV. Macromolecule and enzyme synthesis in cells replicating oncogenic and non-oncogenic human adenovirus, Virology 38: 573–586.PubMedCrossRefGoogle Scholar
  28. Rose, J. A., and Koczot, F. J., 1972, Adenovirus-associated virus multiplication. VII. Helper requirement for viral deoxyribonucleic and ribonucleic acid synthesis, J. Virol. 10: 1–8.PubMedGoogle Scholar
  29. Samulski, R. J., and Shenk, T., 1988, Adenovirus E1B 55-Mr polypeptide facilitates timely cytoplasmic accumulation of adeno-associated virus mRNAs, J. Virol. 62: 206–210.PubMedGoogle Scholar
  30. Samulski, R. J., Berns, K. I., Tan, M., and Muzyczka, N., 1982, Cloning of adeno-associated virus into pBR322: Rescue of intact virus from recombinant plasmid in human cells, Proc. Natl. Acad. Sci. USA 79: 2077–2081.PubMedCrossRefGoogle Scholar
  31. Samulski, R. J., Srivastava, A., Berns, K. I., and Muzyczka, N., 1983, Rescue of adeno-associated virus from recombinant plasmids: Gene correction within the terminal repeats of AAV, Cell 33: 135–143.PubMedCrossRefGoogle Scholar
  32. Smith, J. R., and Lumpkin, C. K. L., Jr., 1980, Loss of gene repression activity: A theory of cellular senescence, Mech. Aging Dev. 13: 387–392.PubMedCrossRefGoogle Scholar
  33. Southern, E. M., 1975, Detection of specific sequences among DNA fragments separated by gel electrophoresis, J. Mol. Biol. 98: 503–517.PubMedCrossRefGoogle Scholar
  34. Spindler, K. R., Eng, C. Y., and Berk, A. J., 1985, An adenovirus early region 1A protein is required for maximal viral DNA replication in growth-arrested human cells, J. Virol. 53: 742–750.PubMedGoogle Scholar
  35. Srivastava, A., 1987, Repication of the adeno-associated virus DNA termini in vitro, Intervirology 27: 138–147.PubMedCrossRefGoogle Scholar
  36. Srivastava, A., and Lu, L., 1988, Replication of the B19 parvovirus in highly enriched hematopoietic progenitor cells from normal human bone marrow, J. Virol. 62: 3505–3509.Google Scholar
  37. Srivastava, A., and Nahreini, P., 1989, Productive infection of quiescent and senescent human diploid fibroblasts by adenovirus 2, Submitted for publication.Google Scholar
  38. Srivastava, A., Lusby, E. W., and Berns, K. I., 1983, Nucleotide sequence and organization of the adeno-associated virus 2 genome, J. Virol. 45: 555–564.PubMedGoogle Scholar
  39. Srivastava, A., Norris, J. S., Reis, R. J. S., and Goldstein, S., 1985, c-Ha-ras-1 proto-oncogene amplification and over-expression during the limited replicative lifespan of normal human fibro-blasts, J. Biol. Chem. 260: 6404–6409.Google Scholar
  40. Stein, G. H., Yanishevsky, R. M., Gordon, L., and Beeson, M., 1982, Carcinogen-transformed human cells are inhibited from entry into S-phase by fusion to senescent cells but cells tansformed by DNA tumor viruses overcome the inhibition, Proc. Natl. Acad. Sci. USA 79: 5287–5291.PubMedCrossRefGoogle Scholar
  41. Yakobson, B., Koch, T., and Winocour, E., 1987, Replication of adeno-associated virus in syn¬chronized cells without the addition of a helper virus, J. Virol. 61: 972–981.PubMedGoogle Scholar
  42. Yamashita, T., and Shimojo, H., 1969, Induction of cellular DNA synthesis by adenovirus 12 in human embryo kidney cells, Virology 36: 351–355.CrossRefGoogle Scholar
  43. Yen, A., and Guernsey, D. L., 1986, Increased c-myc RNA levels associated with the precommitment state during HL-60 myeloid differentiation, Cancer Res. 46: 4156–4161.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Piruz Nahreini
    • 1
    • 2
    • 3
    • 4
  • Arun Srivastava
    • 1
    • 2
    • 3
    • 4
  1. 1.Division of Hematology and OncologyIndiana University School of MedicineIndianapolisUSA
  2. 2.Department of MedicineIndiana University School of MedicineIndianapolisUSA
  3. 3.Department of MicrobiologyIndiana University School of MedicineIndianapolisUSA
  4. 4.Department of ImmunologyIndiana University School of MedicineIndianapolisUSA

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