Abstract
The involution of the thymus gland and subsequent decline of thymic hormone serum levels is involved, to a considerable extent, in the development of age-associated immune deficiency (Weksler and Siskind, 1984). Thymus grafting or substitutive therapy with thymic hormones was reported to improve and/or restore age-associated immune defects in experimental animals (Doria et al., 1986).
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References
Boyum, A., 1968, Isolation of mononuclear cells and granulocytes from human blood, Scand. J. Clin. Lab. Invest. 21 (suppl. 97): 77–81.
Doria, G., Adorini, L., and Frasca, D., 1986, Immunoregulation of antibody responses in aging mice, in: Aging and the Immune Response ( E. Goidl, eds.), Dekker, New York, pp. 143–176.
Duchateau, J., Delespesse, G., and Bolla, K., 1983, Phase variation in the modulation of the human immune response, Immunol. Today 4: 213–214.
Frasca, D., Adorini, L., and Doria, G., 1987, Enhanced frequency of mitogen-responsive T cell precursor in old mice injected with thymosin alpha-1, Eur. J. Immunol. 17: 727–734.
Frazer, I. H., Collins, E. J., Fox, J. S., Jones, B., Oliphant, R. C., and Hackey, I. R., 1985, Assessment of delayed-type hypersensitivity in man: A comparison of the “Multitest” and conventional intradermal injection of six antigens, Clin. Immunol. Immunopathol. 35: 182–190.
Gillis, S., Ferm, M. M., Ou, W., and Smith, K. A., 1978, T cell growth factor: Parameters of production and a quantitative microassay for activity, J. Immunol. 120: 2027–2031.
Goldstein, G., Scheid, M. P., Boyse, E. A., Schlesinger, D. H., and Van Wauwe, J., 1979, A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin, Science 204: 1309–1310.
Meroni, P. L., Barcellini, W., Messina, C., DeBartolo, G., Capsoni, F., and Invernizzi, F., 1982, Defective suppressor cell activity in essential mixed cryoglobulinemia, J. Clin. Lab. Immunol. 8: 177–182.
Meroni, P. L., Barcellini, W., De Bartolo, G., Invernizzi, F., and Zanussi, C., 1984, Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from patients with essential mixed cryoglobulinemia, Clin. Immunol. Immunopathol. 33: 245–257.
Meroni, P. L., Barcellini, W., Frasca, D., Sguotti, C., Borghi, M. O., De Bartolo, G., Doria, G., and Zanussi, C., 1987, In vivo immunopotentiating activity of thymopentin in aging humans, Clin. Immunol. Immunopathol. 42: 151–159.
Ranges, G. E., Scheid, M. P., Goldstein, G., and Boyse, E. A., 1982, T cell development in normal and tymopentin-treated nude mice, J. Exp. Med. 156: 1057–1064.
Robb, R. J., Munck, A., and Smith, K. A., 1981, T cell growth factor receptors: Quantitation, specificity and biological relevance, J. Exp. Med. 154: 1455–1461.
Robb, R. J., Greene, W. C., and Rusk, C., 1984, Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen, J. Exp. Med. 160: 1126–1146.
Scheid, M. P., Goldstein, G., and Boyse, E. A., 1975, Differentiation of T cells in nude mice, Science 190: 1211–1214.
Sette, A., Adorini, L., Marubini, E., and Doria, G., 1986, A microcomputer program for probit analysis of interleukin 2 titration data, J. Immunol. Methods 86: 265–277.
Steel, R. G. D., and Torrie, J. H. (eds.), 1960, Principles and procedures of Statistics, McGraw-Hill, New York.
Fazekas de St. Groth, S., 1982, The evaluation of limiting dilution assay, J. Immunol. Methods 49.
Stutman, O., 1978, Intrathymic and extrathymic T celi maturation, Immunol. Rev. 42: 139.
Sztein, M. B., Serrate, S. A., and Goldstein, A. L., 1986, Modulation of interleukin 2 receptor expression by thymic hormones, Proc. Natl. Acad. Sci. USA 83: 6107–6111.
Uchiyama, T., Broder, S., and Waldmann, T. A., 1981, A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac(+) cells, J. Immunol. 126: 1393–1401.
Weksler, M. E., and Siskind, G. W., 1984, The cellular basis of immune senescence, Monog. Dev. Biol. 17: 110–121.
Zatz, M. M., and Goldstein, A. L., 1985, Thymosin increases production of T cell growth factor by normal human peripheral blood lymphocytes, Proc. Natl. Acad. Sci. USA 81: 2082–2085.
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© 1990 Plenum Press, New York
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Meroni, P.L. et al. (1990). Immunopotentiating Activity of Thymopentin Treatment in Elderly Subjects. In: Goldstein, A.L. (eds) Biomedical Advances in Aging. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0513-2_54
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DOI: https://doi.org/10.1007/978-1-4613-0513-2_54
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