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Alterations in B Cells and Antibodies of Aged Mice

  • Norman R. Klinman
  • Sylvia C. Riley
  • Dorith Zharhary
  • Barbara G. Froscher
  • Gordon D. Powers
  • Phyllis-Jean Linton
Conference paper
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Among the immunologic defects associated with aging is a decrease in humoral immune responses. Much of this decrease in antibody production, particularly in response to T- dependent antigens, is the result of diminished T-cell helper function (Price and Makinodan, 1972; Nordin and Makinodan, 1974, Makinodan, 1972; Krosgrud and Perkins, 1977; Segre and Segre, 1976). However, multiple alterations in B-cell function have also been identified in aged individuals (Callard et al., 1977; Goidl et al., 1976; Kishimoto and Yamamura, 1971; Kishimoto et al., 1976; Zharhary and Klinman, 1983; Zharhary and Klinman, 1986a; Zharhary and Klinman, 1986b). The alterations in B cells of aged mice are generally evidenced in two ways: (1) the decreased amount of antibody production after antigenic stimulation to many but not all antigens (Kishimoto and Yamamura, 1971; Kishimoto et al., 1976; Zharhary and Klinman, 1983, 1986a); and (2) subtle but reproducible alterations in the antibody specificities expressed by immunized aged versus young animals (Goidl et al., 1976, 1980; Zharhary and Klinman, 1983; Szewczuk and Campbell, 1980; Doria et al., 1978). Such changes in B-cell function could be the result of intrinsic differences in the B cells generated in aged versus young individuals or alternatively may reflect the consequences of environmental modulation of expressed B cells that could differ in aged versus young individuals. An example of the latter effect is the well-demonstrated increase in antiidiotype reactivity that appears to accumulate as mice age (Klinman, 1981; Goidl et al., 1980). This increase in anti-idiotypic reactivity dampens the responsiveness of all B cells— even those derived from young mice—when they are placed in the environment of an aged mouse (Klinman, 1981).

Keywords

Aged Mouse Young Mouse Repertoire Diversity Clonal Progeny Idiotypic Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Norman R. Klinman
    • 1
  • Sylvia C. Riley
    • 1
  • Dorith Zharhary
    • 1
  • Barbara G. Froscher
    • 1
  • Gordon D. Powers
    • 1
  • Phyllis-Jean Linton
    • 1
  1. 1.Department of ImmunologyScripps Clinic and Research FoundationLa JollaUSA

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