Neuroendocrine Effects of Lifelong Dietary Restriction by Intermittent Feeding in Mice

  • Barbara J. Davis
  • Robert W. Hamill
  • Thomas H. McNeill
  • Elaine Bresnahan
  • Donald K. Ingram
Conference paper
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Lifelong dietary restriction has been shown to increase mean and maximum life span and to delay the onset of pathophysiologic changes associated with aging in rodents (Barrows and Kokkonen, 1978). The mechanisms underlying the modulation of aging by dietary restriction remain unknown. Based on studies using several levels of dietary restriction in mice, Weindruch et al. (1986) suggested that increased metabolic efficiency may be related to longevity, since the longest-lived mice at each level of dietary restriction studies also were the heaviest. Although a number of studies support the hypothesis that increased body weight is associated with increased longevity in dietarily restricted rodents, (reviewed by Ingram and Reynolds, 1987), the relationship between body weight and life span is complex, and it is difficult to make generalized statements relating longevity to body weight.


Tyrosine Hydroxylase Dietary Restriction Final Body Weight Restricted Feeding Maximum Life Span 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Barbara J. Davis
    • 1
  • Robert W. Hamill
    • 1
  • Thomas H. McNeill
    • 1
  • Elaine Bresnahan
    • 2
  • Donald K. Ingram
    • 3
  1. 1.Department of NeurologyUniversity of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Gerontology Research CenterNational Institute on Aging, National Institutes of Health, Francis Scott Key Medical CenterBaltimoreUSA
  3. 3.Molecular Physiology and Genetics Section, Laboratory of Cellular and Molecular Biology, Gerontology Research CenterNational Institute on Aging, National Institutes of Health, Francis Scott Key Medical CenterBaltimoreUSA

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