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Effects of Various Stimulators and Inhibitors on the Respiratory Burst of PMNL with Aging

  • Zsuzsa Varga
  • Gabriella Foris
  • Sàndor Szucs
  • Tamàs FülöpJr.
  • Andràs Leovey
Conference paper
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

It is well known that the incidence of certain diseases such as infections (Gardner, 1980), atherosclerosis (Stout, 1987), diabetes mellitus (DeFronzo, 1981), and tumors (Doll et al., 1970) is increased with aging. It can be assumed that the cause of this increased incidence is multifactorial, but the decrease of the immune response certainly plays an important role (Makinodan and Kay, 1980; Corberand et al., 1981). It was established that the oxidative burst plays an essential role in the host defense against pathogens and other microorganisms (Johnston et al., 1976; Babior and Crowley, 1983); therefore, an alteration of the respiratory burst could contribute to the increased incidence of infectious diseases with aging.

Keywords

NADPH Oxidase Respiratory Burst Chronic Granulomatous Disease Pertussis Toxin NADPH Oxidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Zsuzsa Varga
    • 1
  • Gabriella Foris
    • 1
  • Sàndor Szucs
    • 1
  • Tamàs FülöpJr.
    • 1
  • Andràs Leovey
    • 1
  1. 1.First Department of MedicineUniversity Medical School of DebrecenDebrecenHungary

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