Abstract
It is well known that elderly subjects are susceptible to infections, cancer, and autoimmune disorders (Gladstone and Recco, 1976; Dollet al., 1970; Blumenthal and Berns, 1964). The immune functions were studied extensively in aged humans and animals; the results suggest that the B- and T-lymphocyte functions were altered, particularly the T-cell-mediated immune response (Weksler, 1983; Makinodan and Kay, 1980; Antonaci et al., 1987). It is thought that this decline contributes in large part to the increased incidence of the above-mentioned diseases. Most of the effector functions that occur during the immune response necessitate the stimulation of specific receptors. Among these functions, the most important are proliferation, differentiation, secretion, and phagocytosis (Michell, 1987; Snyderman and Pike, 1984; Fülöp et al., 1985). A few studies have been concerned with receptors (Roth, 1986; De Weck et al., 1984) and postreceptor signal-transduction mechanisms (Ito et al., 1982; Fülöp et al., 1987b) in the cells of elderly. The aim of this chapter is to elucidate some aspects of the signal-transduction mechanism in the polymorphonuclear leukocytes (PMNL) of elderly subjects.
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© 1990 Plenum Press, New York
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Fülöp, T. et al. (1990). Altered Phosphatidylinositol Breakdown in Polymorphonuclear Leukocytes with Aging. In: Goldstein, A.L. (eds) Biomedical Advances in Aging. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0513-2_17
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DOI: https://doi.org/10.1007/978-1-4613-0513-2_17
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