Polyenoic Fatty Acid Metabolism and Prostaglandin Biosynthesis in Aged Persons

  • Olaf Adam
Conference paper
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The incorporation of polyunsaturated fatty acids (PUFA) in body lipids influences the fluidity of body cells and their capability to form prostaglandins (PG) (Adam and Wolfram, 1984). Recent work has shown that the intake of PUFA has implications on PUFA incorporation (Zöllneret al., 1979), desaturation (Bloj et al., 1973) and PG formation (Adam et al., 1986a,b), which is essential for proper cell function. Aging is a cellular event that may result in impairment of membrane-bound enzymes regulating PUFA metabolism. The objectives of this study were to compare in a group of young adults and in a group of aged persons the incorporation of linoleic acid into plasma lipids. By measuring the elongation product, arachidonic acid, we were able to estimate the activity of the rate-limiting enzyme in this process, the delta-6-desaturase. Finally, we monitored PG formation by measuring the joint urinary metabolite of PGE, PGF, and PGD in 24-hr urine.


Linoleic Acid Arachidonic Acid Aged Person Body Lipid Total Energy Intake 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Olaf Adam
    • 1
  1. 1.Medical PolyclinicUniversity of MunichMunichFederal Republic of Germany

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