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Plasma α-Tocopherol Levels in Men and Women of Different Ages

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Biomedical Advances in Aging

Abstract

The aging process and age-related changes have been linked to the production of free radicals during normal metabolism (Harman, 1981). α-Tocopherol (AT), the fat-soluble vitamin E, a constituent of biomembranes, plays an important role as a chain-breaking antioxidant in protecting biological molecules against oxidative damage (McCay and King, 1980; Burton and Ingold, 1986).

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References

  • Behrens, W. A., Thompson, J. N., and Madere, R., 1982, Distribution of alpha tocopherol in human plasma lipoproteins, Am. J. Clin. Nutr. 35: 691–696.

    PubMed  CAS  Google Scholar 

  • Bittolo-Bon, G., Cazzolato, G., Saccardi, M., and Avogaro, P., 1987, Presence of a modified LDL in humans: Effect of vitamin E, in:, Clinical and Nutrition Aspects of Vitamin E (O. Hayaishi and M. Mino, eds.), Elsevier, Ireland, pp. 109–120.

    Google Scholar 

  • Bjornson, L. K., Kayden, H. J., Miller, E., and Moschell, A. N., 1976, The transport of alpha- tocopherol and beta-carotene in human blood, J. Lipid Res. 17: 343–352.

    PubMed  CAS  Google Scholar 

  • Brown, M. S., and Goldstein, J. L., 1983, Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis, Annu. Rev. Biochem. 52: 223–261.

    Article  PubMed  CAS  Google Scholar 

  • Burton, G. W., and Ingold, K. U., 1986, Vitamin E: Application of the principles of physical organic chemistry to the exploration of its structure and function, Acc. Chem. Res. 19: 194–201.

    Article  CAS  Google Scholar 

  • Farrell, P. M., Levine, S. L., Murphy, D., and Adams, A. J., 1978, Plasma tocopherol levels and tocopherol lipid relationships in a normal population of children as compared to healthy adults, Am. J. Clin. Nutr. 31: 1720–1726.

    PubMed  CAS  Google Scholar 

  • Gallo-Torres, H. E., 1980, Transport and Metabolism, in: Vitamin E. A Comprehensive Treatise ( L. J. Machlin, ed.), Dekker, New York, pp. 289–347.

    Google Scholar 

  • Gontzea, I., and Nicolau, N., 1972, Relationship between serum tocopherol level and dyslipidemia, Nutr. Rep. Int. 5: 225–230.

    CAS  Google Scholar 

  • Gordon, T., Castelli, W. P., Hjortland, M. C., Kannell, W. B., and Dawber, T. R., 1977, High density lipoprotein as a protective factor against coronary heart disease, The Framingham Study, Am. J. Med. 62: 707–714.

    Article  PubMed  CAS  Google Scholar 

  • Harding, A. E., Matthews, S., Jones, S., Ellis, C. J. K., Booth, I. W., and Muller, D. P. R., 1985, Spinocerebellar degeneration associated with a selective defect of vitamin E absorption, N. Engl. J. Med. 313: 32–35.

    Article  CAS  Google Scholar 

  • Harman, D., 1981, The aging process, Proc. Natl. Acad. Sci. USA 78: 7124–7128.

    Article  PubMed  CAS  Google Scholar 

  • Havel, R. J., Goldstein, J. L., and Brown, M. S., 1980, Lipoprotein and lipid transport, in: Metabolic Control and Disease, 8th ed. ( P. K. Bondy and L. E. Rosenberg, eds.), W. B. Saunders, Philadelphia, pp. 393–494.

    Google Scholar 

  • Herbert, P. M., Assman, G., Gotto, A. M., Jr., and Fredrickson, D. S., 1983, Familial lipoprotein deficiency: Abetalipoproteinemia, hypobetalipoproteinemia, and Tangier disease, in: Metabolic Basis of Inherited Disease ( J. B. Stambury, J. B. Wyngaarden, D. S. Fredrickson, J. L. Goldstein, and M. S. Brown, eds.), McGraw-Hill, New York, pp. 589–621.

    Google Scholar 

  • Herman, W. J., Ward, K., and Faucett, J., 1979, The effect of tocopherol on high-density lipoprotein cholesterol. A clinical observation, Am. J. Clin. Pathol. 72: 848–852.

    Google Scholar 

  • Horwitt, M. K., Harvey, C. C., Dahm, C. H., Searcy, M. T., 1972, Relationship between tocopherol and serum lipid level for determination of nutritional adequacy, Ann. N.Y. Acad. Sci. 203: 223–236.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, J. S., Pian, A. K., Baer, M. T., Acosta, P. B., and Emerson, G. A., 1973, Effect of long-term ingestion of polyunsaturated fat, age, plasma cholesterol, diabetes mellitus and supplemental tocopherol, Am. J. Clin. Nutr., 26: 136–143.

    PubMed  CAS  Google Scholar 

  • Lipid Research Clinics Program Epidemilogy Committee, 1979, Plasma lipid distribution in selected North American populations: The Lipid Research Clinics Program Prevalence Study, Circulation 60: 427–439.

    Google Scholar 

  • Lopes-Virella, M. F., Stone, P., Ellis, S., and Colwell, J. A., 1977, Cholesterol determination in high-density lipoproteins separated by three different methods, Clin. Chem. 23: 882–884.

    PubMed  CAS  Google Scholar 

  • McCay, P. B., and King, M., 1980, Biochemical function, in: Vitamin E. A Comprehensive Treatise ( L. J. Machlen, ed.), Marcel Dekker, New York, pp. 289–494.

    Google Scholar 

  • Miller, G. J., and Miller, N. F., 1975, Plasma high density lipoprotein concentration and development of ischaemic heart disease, Lancet 1: 16–19.

    Article  PubMed  CAS  Google Scholar 

  • Schneider, E. L., and Reed, J. D., 1985, Modulations of aging processes, in: Handbook of the Biology of Aging, 2nd ed. ( C. E. Finch and E. L. Schneider, eds.), Van Nostrand-Reinhold, New York, pp. 45–76.

    Google Scholar 

  • Serfontein, W. J., Ubbinink, J. B., and De Villiers, L. S., 1983, Further evidence on the effect of vitamin E on the cholesterol distribution in lipoproteins with special reference to HDL subfractions, Am. J. Clin. Pathol. 79: 604–606.

    CAS  Google Scholar 

  • Sokol, R. J., Heubi, J. E., Iannaccone, S. T., Bove, K. E., and Balistrieri, W. F., 1984, Vitamin E deficiency with normal serum vitamin E concentrations in children with chronic cholestasis, N. Engl. J. Med. 310: 1209–1212.

    Article  PubMed  CAS  Google Scholar 

  • Steinberg, D., 1983, Lipoproteins and atheroscloerosis: A look back and a look ahead. Artheriosclerosis 3: 283–301.

    Article  CAS  Google Scholar 

  • Traber, M. G., and Kayden, H. J., 1984, Vitamin E is delivered to cells via the high affinity receptor to low-density lipoprotein, Am. J. Clin. Nutr. 40: 747–751.

    PubMed  CAS  Google Scholar 

  • Vanderwoude, M. F. J., and Vanderwoude, M. G., 1987, Vitamin E status in a normal population: The influence of age, J. Am. College Nutr. 6: 307–311.

    Google Scholar 

  • Vatassery, G. T., Krezowski, A. M., and Eckfeldt, J. H., 1983, Vitamin E concentrations in human blood plasma and platelets, Am. J. Clin. Nutr. 37: 1020–1024.

    PubMed  CAS  Google Scholar 

  • Vuilleumier, J. P., Keller, H. E., Gysel, D., and Hunziker, F., 1983, Clinical chemical methods for the routine assessment of the vitamin status in human populations. I. The fat-soluble vitamin A and E and beta carotene, Int. J. Vitam. Nutr. Res. 53: 265–272.

    CAS  Google Scholar 

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© 1990 Plenum Press, New York

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Vergani, C., Stefanoni, P., Grazioli, M., Clerici, M. (1990). Plasma α-Tocopherol Levels in Men and Women of Different Ages. In: Goldstein, A.L. (eds) Biomedical Advances in Aging. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0513-2_15

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  • DOI: https://doi.org/10.1007/978-1-4613-0513-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7844-3

  • Online ISBN: 978-1-4613-0513-2

  • eBook Packages: Springer Book Archive

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