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Molecular Aging of Membrane Molecules and Cellular Removal

  • Marguerite M. B. Kay
Conference paper
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Investigations into mechanisms by which macrophages distinguish mature from senescent calf cells showed that a glycoprotein, senescent cell antigen, a terminal differentiation antigen, appears on the surface of senescent cells (Kay, 1974, 1975, 1978, 1981a–c, 1982a; Bennett and Kay, 1981; Kay and Bennett, 1982; Kay et al., 1982). It is recognized by the antigen-binding Fab region (Kay, 1978) of a specific immunoglobulin G (IgG) autoantibody in serum that attaches to cells carrying senescent cell antigen and initiates their removal by marcophages (Kay, 1975, 1978). Senescent cell antigen was first observed on the surface of senescent human erythrocytes (Kay, 1974, 1975) but has since been demonstrated on the surface of lymphocytes, polymorphonuclear leukocytes, platelets, embryonic kidney cells, and adult liver cells (Kay, 1981a).

Keywords

Senescent Cell Anion Transport Molecular Aging Ninth International Symposium Senescent Erythrocyte 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Marguerite M. B. Kay
    • 1
    • 2
    • 3
  1. 1.Department of MedicineTexas A&M University, and Teague Veterans CenterTempleUSA
  2. 2.Department of Medical Biochemistry and GeneticsTexas A&M University, and Teague Veterans CenterTempleUSA
  3. 3.Department of Medical Microbiology and ImmunologyTexas A&M University, and Teague Veterans CenterTempleUSA

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