Changes in Receptors and Signal Transduction Events during Aging
Physiological and behavioral responses to many classes of stimuli are altered during aging. Best studied among these have been hormone and neurotransmitter signal transduction sequences. Age-related alterations in these processes have been grouped into receptor and postreceptor changes. Our laboratory has focused on three systems that exhibit representative age-associated alterations in signal transduction mechanisms: (1) dopaminergic regulation of motor function, (2) estrogenic regulation of uterine anabolic function, and (3) α-adrenergic regulation of parotid secretory function (for review, see Roth, 1985).
KeywordsPhorbol Myristate Acetate Inositol Trisphosphate Signal Transduction Event Estrogenic Regulation Gland Acinar Cell
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