Chronic Diseases and Disorders
Two classes of age-associated diseases and disorders, one age-dependent and the other age-related, are suggested to provide a utilitarian hypothesis with research preventive and therapeutic implications. Molecular and immunological mechanisms pertinent to causality and progression are likely to be distinctive for these two classes. Age-dependent diseases and disorders are defined as those whose pathogenesis directly involves the aging of the host; thus, morbidity and mortality related to these diseases follows the age-specific death rate, which increases exponentially from about 35 years on (Fig. 1). Age-related diseases and disorders are those which have specific temporal patterns for their occurrence but after a certain time in life, new cases cease to occur. Thus, the body appears to have become resistant to this class.
KeywordsOsteoporosis Schizophrenia Osteoarthritis Purine Gout
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