Chronic Diseases and Disorders

A Hypothesis Suggesting an Age-Dependent versus an Age-Related Class
  • Jacob A. Brody
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Two classes of age-associated diseases and disorders, one age-dependent and the other age-related, are suggested to provide a utilitarian hypothesis with research preventive and therapeutic implications. Molecular and immunological mechanisms pertinent to causality and progression are likely to be distinctive for these two classes. Age-dependent diseases and disorders are defined as those whose pathogenesis directly involves the aging of the host; thus, morbidity and mortality related to these diseases follows the age-specific death rate, which increases exponentially from about 35 years on (Fig. 1). Age-related diseases and disorders are those which have specific temporal patterns for their occurrence but after a certain time in life, new cases cease to occur. Thus, the body appears to have become resistant to this class.


Amyotrophic Lateral Sclerosis Ulcerative Colitis Normal Aging Progressive Multifocalleukoencephalopathy DHHS Publication 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jacob A. Brody
    • 1
  1. 1.School of Public HealthUniversity of Illinois at ChicagoChicagoUSA

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