Abstract
Two classes of age-associated diseases and disorders, one age-dependent and the other age-related, are suggested to provide a utilitarian hypothesis with research preventive and therapeutic implications. Molecular and immunological mechanisms pertinent to causality and progression are likely to be distinctive for these two classes. Age-dependent diseases and disorders are defined as those whose pathogenesis directly involves the aging of the host; thus, morbidity and mortality related to these diseases follows the age-specific death rate, which increases exponentially from about 35 years on (Fig. 1). Age-related diseases and disorders are those which have specific temporal patterns for their occurrence but after a certain time in life, new cases cease to occur. Thus, the body appears to have become resistant to this class.
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References
Brody, J. A., and Schneider, E. L., 1986, Diseases and disorders of aging: an hypothesis, J. Chron. Dis. 39: 871–876.
Schneider, E. L., and Brody, J. A., 1983, Aging, natural death, and compression of morbidity: Another view, N. Engl. J. Med. 309: 854–856.
Siegel, J. S., 1980, Recent and prospective demographic trends for the elderly population and some implications for health care, in: Proceedings of the Second Conference on the Epidemiology of Aging, NIH Publication No. 80–969, U.S. Government Printing Office, Washington, D.C.
Taeuber, C. M., 1983, America in Transition: An Aging Society, Current Population Reports, Special Studies, Series P-23, No. 128, U.S. Department of Commerce, Bureau of the Census, Washington, D.C.
United States National Center for Health Statistics, 1980, Vital Statistics of the United States, Vol. II: Mortality, Part A, Advance Report on Final Mortality Statistics, 1978. Hyattsville, Maryland, Vol. 29, No. 6 (Suppl.), DHHS Publication No. (PHS)-F-80-1120.
United States National Center for Health Statistics, 1983, Changing Mortality Patterns, Health Services Utilization, and Health Care Expenditures. United States, 1978–2003. Hyattsville, Maryland, NCHS Analytical and Epidemiological Studies, Vital and Health Statistics, Series 3, No. 23, DHHS publication No. (PHS)83-1407).
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© 1990 Plenum Press, New York
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Brody, J.A. (1990). Chronic Diseases and Disorders. In: Goldstein, A.L. (eds) Biomedical Advances in Aging. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0513-2_11
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DOI: https://doi.org/10.1007/978-1-4613-0513-2_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7844-3
Online ISBN: 978-1-4613-0513-2
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