Nicotine, Cocaine and Amphetamine Share Several Common Mechanisms of c-fos Induction in the Striatum: Implications for the Functions of the Striatum
The striatum (nucleus accumbens and the caudatoputamen) receives dense dopaminergic input form several subdivisions of the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc) (Fallon, 1988). Different human neurological disorders and varieties of animals models that have manipulated the striatal dopaminergic innervation have suggested that dopamine plays a major role in integrating the various inputs and the neurotransmitter systems intrinsic to the striatum. Dysfunctions of the dopaminergic input to the striatum result in a complex spectrum of hypo- and hyperkinetic as well as brady- and hyperphrenic syndromes. Our understanding of the functions of the basal ganglia clearly depends on better definition of the role played by the dopamine in the striatum.
KeywordsDopamine Nicotine Morphine Cocaine NMDA
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