Abstract
What the basal ganglia do, is it the on-going question? New models have reevaluated the input/output ratio of single structures as inserted in parallel, functional systems (Alexander and Crutcher, 1990). These models have reinforced the assumption that the basal ganglia are a key station for the execution of organized movements (DeLong, 1990; Goldman-Rakic and Selemon, 1990). At the molecular level, new families of receptors are explored. The cloning of glutamate metabotropic receptors is heading the surprising multiplicity of the neurobiology of excitatory transmission (Gasic, 1992). The definition of new subclasses of dopamine receptors is an invitation to reconsider the pharmacology of the amine (Surmeier et al., 1992). Radical changes, however, in the therapy of movement disorders have barely taken place, being the introduction of levo-dopa still a “cornerstone” of the therapy of the parkinsonian patient (Hornykiewicz, 1966). Whatever are the fundamental functions of the basal ganglia, a striking dichotomy risks to develop between basic research acquisition and the daily urgency of patient’s quality of life. In presenting our recent findings, we aim to highlight those aspects of mesencephalic, neostriatal and pallidal physiology whose clinical impact could be relevant.
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References
Alexander, G.E., and Crutcher, M.D., 1990, Functional architecture of basal ganglia circuits; neural substrate of parallel processing, Trends Neurosci. 13:266–271.
Calabresi, P., Mercuri, N.B., and Bernardi, G., 1990, Synaptic and intrinsic control of membrane excitability of neostriatal neurons. II: an in vitro study, J. Neurophysiol. 63:663–675.
Calabresi, P., Maj, R., Mercuri, N.B., and Bernardi, G, 1992a, Coactivation of Dl and D2 dopamine receptors is required for long-term depression in neostriatum, Neurosci. Lett. 142:95–99.
Calabresi, P., Pisani, A., Mercuri, N.B., and Bernardi, G., 1992b, Long-term potentiation in the striatum is unmasked by removing the voltage-dependent block of NMDA receptors channels, Eur. J. Neurosci. 4:929–935.
Calabresi, P., Pisani, A., Mercuri, N.B., and Bernardi, G., 1992c, Long-term synaptic depression in the striatum:physiological and pharmacological characterization, J. Neuroscience 92:4224–4333.
Calabresi, P., Pisani, A., Mercuri, N.B., Bernardi, G., 1993, Lithium-treatment blocks LTD in the striatum, Neuron in press.
Choi, D.W., 1988, Glutamate neurotoxicity and disease of the nervous system, Neuron 7:357–367.
Collingridge, G.L., and Singer, W., 1990, Excitatory amino acid receptors and synaptic plasticity, Trends Pharmacol. Sci. 11:290–296.
DeLong, M.R., 1990, Primate models of movement disorders of basal ganglia origin, Trends. Neurosci 13:281–285.
Gasic, G.P., 1992, Molecular neurobiology of glutamate receptors, Ann. Rev. Physiol. 54:507–536.
Goldman-Rakic, P.S., and Selemon, L.D., 1990, New frontiers in basal ganglia research, Trends Neurosci. 13:241–244.
Hornykiewicz, O., 1966, Dopamine and brain function, Pharmacol. Rev. 18:925–964.
Ito, M., 1989, Long-term depression, Ann. Rev. Neurosci. 12:85–102.
Kita, H., and Kitai, ST., 1991, Intracellular study of rat globus pallidus neurons:membrane properties and responses to neostriatal, subthalamic and nigral stimulation, Brain Res. 564:296–305.
Lacey, M.G., Mercuri, N.B., and North, R.A., 1987, Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta, J. Physiol. 392:397–416.
Mercuri, N.B., Stratta, F., Calabresi, P., and Bernardi, G., 1991, Electrophysiological effects of amineptine on neurones of the rat substantia nigra pars compacta:evidence for an inhibition of the dopamine uptake system, Br. J. Pharmacol., 104:700–704.
Mercuri, N.B., Stratta, F., Calabresi, P., and Bernardi, G., 1992a, Electrophysiological evidences for the presence of ionotropic and metabotropic excitatory amino acid receptors on dopaminergic neurons of the rat mesencephalon:an in vitro study, Funct. Neurol. 7:231–234.
Mercuri, N.B., Calabresi, P., and Bernardi, G, 1992b, Electrophysiological actions of dopamine and dopaminergic drugs on neurones of the substantia nigra pars compacta and ventral tegmental area, Life Sci. 51:711–718.
Mercuri, N.B., Stratta, F., Calabresi, P., and Bernardi, G., 1993, A voltage-clamp analysis of NMDA-induced responses on dopaminergic neurons of the rat substantia nigra zona compacta and ventral tegmental area, Brain Res. 593:51–56.
Mereu, G., Costa, E., Armstrong, D.M., and Vicini, S., 1991, Glutamate receptor subtypes and excitatory synaptic currents of dopamine neurons in midbrain slices, J. Neurosci. 11:1350–1356.
Percheron, G., Yelnik, J., and Francois, C, 1984, A Golgi analysis of the primate globus pallidus. Ill:spatial organization of the striatopallidal complex, J. Comp. Neurol. 227:214–227.
Robertson, H.A., 1992, Dopamine receptor interactions:some implications for the treatment of Parkinson’s disease, Trends Neurosci. 15:201–206.
Sonsalla, P.K., Riordan, D.E., and Heikkila, R.E., 1989, Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic neurotoxicity, Science 243:398–400.
Stefani, A., Calabresi, P., Mercuri, N.B., and Bernardi, G., 1992, A-current in rat globus pallidus:a whole-cell voltage–clamp study on acutely dissociated neurons, Neurosci. Lett. 144:4–8.
Stefani, A., Surmeier, DJ, Bernardi, G., 1993, The µ-agonist DAGO decreases HVA calcium currents in acutely dissociated neostriatal neurons, Eur. J. Neuroscience submitted.
Surmeier, DJ., Stefani, A., Foehring, R., and Kitai, S.T., 1991, Developmental expression of a slowly-inactivating current in rat neostriatal neurons, Neurosci. Lett. 122:41–46.
Surmeier, DJ., Eberwine, J., Wilson, C.J., Cao, Y., Stefani, A., and Kitai, ST., 1992, Dopamine receptor subtypes colocalize in rat striatonigral neurons, Proc. Nat. Acad. Sci.USA 89:10178–10182.
Turski, L., Bressler, K., Retting, K.J., Loschmann, P.A., and Wachtel, H., 1991, Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-d-aspartate antagonists, Nature 349:415–418.
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© 1994 Plenum Press, New York
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Stefani, A. et al. (1994). Basic Electrophysiology and Possible New Therapeutic Approaches to Movement Disorders. In: Percheron, G., McKenzie, J.S., Féger, J. (eds) The Basal Ganglia IV. Advances in Behavioral Biology, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0485-2_24
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DOI: https://doi.org/10.1007/978-1-4613-0485-2_24
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