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Alterations in Energy Substrate Metabolism During Oxidative Stress

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Purines and Myocardial Protection

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 181))

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Abstract

The cardioprotective effects of adenosine, that have been observed in numerous conditions associated with myocardial ischemia (stunning, regional and global reperfusion injury, myocardial infarction and cardioplegic arrest) have been reviewed in detail in this text and elsewhere, e.g. (1,2). Of great interest is the observation that adenosine appears to mimic ischemic preconditioning, a process by which a brief period of ischemia alters myocardial metabolism and renders the heart more tolerant to a subsequent prolonged period of ischemia (2). The precise mechanisms underlying the beneficial effects of adenosine and preconditioning are not fully understood, but it is clear that adenosine, whether released from the heart during ischemia, or whether administered exogenously, can exert multiple actions, many of which are potentially protective.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada

    Alexander S. Clanachan & Gary D. Lopaschuk

  2. Department of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada

    Gary D. Lopaschuk

Authors
  1. Alexander S. Clanachan
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  2. Gary D. Lopaschuk
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Editor information

Editors and Affiliations

  1. Cardiothoracic Division, Department of Surgery, Box 890532, MCV Station, Richmond, VA, 23298-0532, USA

    Anwar-Saad A. Abd-Elfattah MS, Ph.D.

  2. Department of Surgery, Medical College of Virginia, Richmond, Virginia, 23298-0532, USA

    Andrew S. Wechsler M.D.

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© 1996 Kluwer Academic Publishers

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Clanachan, A.S., Lopaschuk, G.D. (1996). Alterations in Energy Substrate Metabolism During Oxidative Stress. In: Abd-Elfattah, AS.A., Wechsler, A.S. (eds) Purines and Myocardial Protection. Developments in Cardiovascular Medicine, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0455-5_7

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  • DOI: https://doi.org/10.1007/978-1-4613-0455-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8056-6

  • Online ISBN: 978-1-4613-0455-5

  • eBook Packages: Springer Book Archive

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