Energy and Cation Control in the Reoxygenated Myocardial Cell

  • H. Michael Piper
  • Yury V. Ladilov
  • Berthold Siegmund
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 181)


The development of cell injury in ischemic tissue starts with a deficit in the cellular balance of energy. The energetic deficit leads to a slowdown or cessation of important metabolic functions, among these the cellular control of Na+ and Ca 2+ ions. When the cellular reserves of energy are depleted, cation pumps regulating the normal intracellular ionic milieu fail due to a lack of energy. A lone-lasting overload of the cytosolic space and intracellular organelles with excess Car 2+ can be deleterious for the cell, as a number of structure degrading processes may become activated. In muscle cells, the activation of the myofibrillar contractile apparatus by high levels of Ca 2+ may additionally cause mechanical cell damage. The loss of cellular Ca 2+ homeostasis is a sign of advanced, but not necessarily irreversibly cell injury. For a better understanding of the pathogenesis of progressive myocardial injury the energy and cation control in the oxygen deprived and reoxygenated cardiomyocyte must be analyzed. This article provides a brief review.


Sarcoplasmic Reticulum Myocardial Cell Intracellular Acidosis Contractile Machinery Cation Control 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • H. Michael Piper
    • 1
  • Yury V. Ladilov
    • 1
  • Berthold Siegmund
    • 1
  1. 1.Physiologisches InstitutJustus-Liebig-UniversitätGiessenGermany

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