The Relationship between The KATP Channel and Myocardial Preconditioning

  • Garret J. Gross
  • Derek M. Yellon
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 179)


The Role of the ATP-sensitive potassium channel (KATP) in Myocardial Ischemia: Since the original discovery of the KATP channel by Noma (1) in 1983, numerous studies have been performed in whole cells and membrane patches to determine the factors which regulate its activity in the heart, and in addition to ATP, a number of endogenous modulators of KATP channel activity have been identified. These include adenosine, the ADP/ATP ratio, certain nucleotide diphosphates, Mg++, pH, lactate and protein kinase C (2,3).


Ischemia Adenosine Cardiol Acetylcholine Noma 


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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Garret J. Gross
    • 1
  • Derek M. Yellon
    • 2
  1. 1.Department of Pharmacology & ToxicologyMedical College of WisconsinMilwaukeeUSA
  2. 2.The Hatter Institute, Department of Academic & Clinical CardiologyUniversity College London Medical School, & HospitalLondonUK

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