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Novel Microbial Transformations of Steroids

  • K. M. Madyastha
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 405)

Abstract

In recent years, reactions catalyzed by microbes or their enzymes have been extensively evaluated from the viewpoint of synthetic organic chemistry. These biocatalysts offer greater specificity than conventional organic reactions and hence used as reagents to carry out certain specific chemical reactions. Microbes find use in the synthesis and production of pharmacologically active steroids. Microbial transformation of steroids was recognised after the successful llα-hydroxylation of progesterone by the fungus, Rhizopus arrhizus.1 Microorganisms can be efficiently used to carry out hydroxylation of a steroid molecule at specific positions. A significant amount of work has already been carried out on the microbial steroid transformations.2–4. We isolated two versatile microorganisms identified as Mucor piriformis and Moraxella sp. that carry out novel and preparatively useful transformations of some steroids. The unique properties of these two microorganisms as biocatalyst are presented.

Keywords

Mineral Salt Medium Microbial Transformation Microbial Conversion Rhizopus Arrhizus Cladosporium Herbarum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • K. M. Madyastha
    • 1
  1. 1.Department of Organic ChemistryIndian Institute of ScienceBangaloreIndia

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