Effects on Mouse Thymocyte Biology

A Mini-Overview with Some New Evidence
  • David W. Ou
  • Mei-ling Shen
  • Ken M. Anderson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 402)


The alkaloid designated cocaine, derived from the leaves of the Anean coca bush (Erythroxylon coca) was first isolated and identified in 1860 by the German chemist, Albert Niemann. Cocaine is used medically in nasal surgery as a topical anesthesia but most of its interest is related to its potential as a powerful addicting narcotic. Its ready availability and the ease with which its use leads to psychological compulsion and physical dependency provides an important impetus for understanding its mechanisms of action, both on the nervous system and other organ systems.


Cocaine Injection Peripheral Blood Mononuclear Cell Culture Cocaine Concentration Erythroxylon Coca Normal Thymocyte 
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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • David W. Ou
    • 1
  • Mei-ling Shen
    • 1
  • Ken M. Anderson
    • 2
  1. 1.Department of PathologyUniversity of Illinois at ChicagoUSA
  2. 2.Departments of Medicine and BiochemistryRush Medical CollegeChicagoUSA

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