Effects on Mouse Thymocyte Biology
The alkaloid designated cocaine, derived from the leaves of the Anean coca bush (Erythroxylon coca) was first isolated and identified in 1860 by the German chemist, Albert Niemann. Cocaine is used medically in nasal surgery as a topical anesthesia but most of its interest is related to its potential as a powerful addicting narcotic. Its ready availability and the ease with which its use leads to psychological compulsion and physical dependency provides an important impetus for understanding its mechanisms of action, both on the nervous system and other organ systems.
KeywordsCocaine Injection Peripheral Blood Mononuclear Cell Culture Cocaine Concentration Erythroxylon Coca Normal Thymocyte
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- 3.Chambers, HF, Morris DL, Tauber MG, Modin G, Cocaine use and the risk for endocarditis in intravenous drug users. Ann. Intern. Med., 106, 833–836, 1987.Google Scholar
- 6.Peterson PK. Gekker G, Chao CC, Schut R, Verhoef J, Edelman CK, Erice A, and Balfour HI-I, Cocaine amplifies HIV-1 replication in cytomegalovirus-stimulated peripheral blood mononuclear cell cocultures. J. Immunol., 140, 676-680, 1992.Google Scholar
- 8.Watson ES, Murphy JC, Elsohly MA. Elsohly HN, and Turner CE, Effects of the administration of coca alkaloids on the primary immune responses of mice: interaction with delta-9-tetrahydrocannabinol and ethanol, Toxicol. Appl. Pharmacol., 71, 1. 1983.Google Scholar
- 17.Klein TW, Newton C., and Friedman H, Cocaine effects on cultured lymphocytes. Drugs of Abuse, Immunity, and Inmiunodeficiency, 151–158, 1991.Google Scholar
- 19.Abbas AK, Lichtman AH, and Pober JS, Cellular & Molecular Immunology, 179–182, 1991.Google Scholar
- 20.Hagen KL, Shen ML, and Ou DW, The effects of cocaine on cellularity, subclass composition, and apoptosis of the mouse thymus. J. Immunol., 152, 6, 113 (3328), 1994Google Scholar