Effects of Tea on Carcinogenesis in Animal Models and Humans

  • Chung S. Yang
  • Laishun Chen
  • Mao-Jung Lee
  • Janelle M. Landau
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 401)

Abstract

The effects of tea consumption on cancer is an area of great scientific and public interest, and this topic was reviewed in 1993 in an article entitled “Tea and Cancer.”1 Since then more than one hundred new research articles related to this topic have been published. In this chapter, we review the available evidence from laboratory and epidemiological studies concerning the effects of tea on cancer formation. Possible mechanisms by which tea components inhibit carcinogenesis are discussed based on the results of some new studies.

Keywords

Adenoma Influenza Oncol Caffeine Turkey 

Abbreviations

EGCG

(-)-epigallocatechin gallate

EGC

(-)-epigallocatechin

ECG

(-)-epicatechin-3-gallate

EC

(-)-epicatechin

NDEA

N-nitrosodiethylamine

DGT

decaffeinated green tea

DBT

decaffeinated black tea

NNK

4-(methylnitrosamino)-1

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References

  1. 1.
    Yang, C. S., Wang, Z.-Y., Tea and Cancer: Areview, J Natl Cancer Inst (Invited Review) 58: 1038–1049 (1993).CrossRefGoogle Scholar
  2. 2.
    Graham, H. N., Green tea composition, consumption, and polyphenol chemistry, Prev. Med. 21: 334–350 (1992).CrossRefGoogle Scholar
  3. 3.
    Wang, Z. Y, Hong, J.-Y, Huang, M.-T., Reuhl, K., Conney, A. H., Yang, C. S., Inhibition of N-nitroso-diethylamine and 4-(methylnitrosamino)-1-(3-pridyl)-1-butanone-induced tumorigenesis in A/J mice by green tea and black tea, Cancer Res. 52: 943–1947 (1992).Google Scholar
  4. 4.
    Shi, S. T., Wang, Z.-Y, Smith, T. J., Hong, J.-Y, Chen, W.-R, Ho, C.-T., Yang, C. S., Effects of green tea and black tea on 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone bioactivation, DNA methylation, and lung tumorigenesis by green tea and black tea in A/J mice, Cancer Res. 54: 4641–4647 (1994).Google Scholar
  5. 5.
    Wang, Z.-Y, Kan, W. A., Mukhtar, H., Protection against benzo(a)pyrene and N-nitrosodiethylamine-induced lung and forestomach tumorigenesis in A/J mice by water extracts of green tea and licorice, Carcinogenesis 13: 1491–1493 (1992).CrossRefGoogle Scholar
  6. 6.
    Katiyar, S. K., Agarwal, R., Zaim, M. T., Mukhtar, H., Protection against Af-nitrosodiethylamine and benzo(a)pyrene-induced forestomach and lung tumorigenesis in A/J mice by green tea, Carcinogenesis 14: 849–855 (1993).CrossRefGoogle Scholar
  7. 7.
    Xu, Y, Ho, C.-T., Amin, S. G., Han, C, Chung, F.-L., Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants, Cancer Res. 52: 3875–3879 (1992).Google Scholar
  8. 8.
    Wang, Z.-Y, Wang, L.-D., Lee, M.-J., Ho, C.-T., Huang, M.-T., Conney, A. H., Yang, C. S., Inhibition of Af-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by green and black tea, Carcino genesis 16: 2143–2148 (1995).CrossRefGoogle Scholar
  9. 9.
    Han, C, Xu, Y, The effect of Chinese tea on the occurrence of esophageal tumors induced by N-ni-trosomethylbenzylamine in rats, Biomed. Environ. Sci. 3: 35–42 (1990).Google Scholar
  10. 10.
    Xu, Y, Han, C, The effect of Chinese tea on the occurrence of esophageal tumors induced by N-ni- trosomethylbenzylamine formed in vivo, Biomed. Environ. Sci. 3 (4): 406–412 (1990).Google Scholar
  11. 11.
    Cheng, S.-J., Ding, L., Zhen, Y.-S., Lin, P.-Z., Zhu, Y.-J., Chen, Y.-Q., Hu, X.-Z., Progress in studies on the antimutagenicity and anticarcinogenecity on green tea epicatechins, Chinese Med. Sci. J. 6: 233–238 (1991).Google Scholar
  12. 12.
    Gao, G. D., Zhou, L. R, Qi, G., Wang, H. S., Li, T. S., Studies of antitumorigenesis by green tea (animal test and flow cytometry), Tumor (Chinese) 10: 42–44 (1990).Google Scholar
  13. 13.
    Yan, Y. S., The experiment of tumor-inhibiting effect of green tea extract in animals and humans, Chung Hua YuFang I Hsueh Tsa Chih 27(3): 129–131 (1993).Google Scholar
  14. 14.
    Yamane, T., Takahashi, T., Kuwata, K., Oya, K., Inagake, M., Kitao, Y, Suganuma, M., Fujiki, H., Inhibition of N-methyl-N’-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach, Cancer Res. 55: 2081–2084 (1995).Google Scholar
  15. 15.
    Wang, Z. Y, Huang, M. T, Ferraro, T., Wong, C. Q., Lou, Y R., Reuhl, K., Iatropoulos, M., Yang, C. S., Conney, A. H., Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-cetate in the skin of SKH-1 mice, Cancer Res 52: 1162–1170 (1992).Google Scholar
  16. 16.
    Wang, Z. Y, Huang, M.-T., Lou, Y.-R., Xie, J.-G., Reuhl, K., Newmark, H. L., Ho, C.-T, Yang, C. S., Conney, A. H., Inhibitory effects of black tea, green tea, decaffeinated black tea and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7, 12-dimethylbenz(a)anthracene-initiated SKH-1 mice, Cancer Res. 54: 3428–3435 (1994).Google Scholar
  17. 17.
    Wang, Z. Y, Huang, M.-T., Ho, C.-T., Chang, R., Ma, W, Ferraro, T., Reuhl, K. R., Yang, C. S., Conney, A. H., Inhibitory effect of green tea on the growth of established skin papillomas in mice, Cancer Res. 52: 6657–6665 (1992).Google Scholar
  18. 18..
    Wang, Z.-Y, Chen, L., Lee, M.-J., Yang, C. S., Tea and cancer prevention, in: Hypernutritions Food (Finley, J. W., Armstrong, D., Robinson, S. F., Nagy, S., eds.), American Chemical Society Symposium, (1995) (in press).Google Scholar
  19. 19.
    Hirose, M., Hoshiya, T., Akagi, K., Takahashi, S., Hara, Y, Ito, N., Effects of green tea catechins in a rat multi-organ carcinogenesis model, Carcinogenesis 14: 1549–1553 (1993).CrossRefGoogle Scholar
  20. 20.
    Hirose, M., Hoshiya, T., Akagi, K., Futakuchi, M., Ito, N., Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7, 12,dimethylbenz(a)anthracene, Cancer Lett. 83: 149–156 (1994).CrossRefGoogle Scholar
  21. 21.
    Narasiwa, T., Fukaura, Y., A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-itrosourea-induced colon carcinogenesis in F344 rats, Jpn. J. Cancer Res. 84: 1007–1009 (1993).Google Scholar
  22. 22.
    Mao, R., The inhibitory effects of epicatechin complex on diethylnitrosamine induced initiation of hepatocarcinogenesis in rats, Chung-Hua-Yu-Fang-I-Hsueh-Tsa-Chih 27: 201–204 (1993).Google Scholar
  23. 23.
    Nishida, H., Omori, M, Fukutomi, Y, Ninomiya, M., Nishiwaki, S., Suganuma, M., Moriwaki, H., Mutao, Y, Inhibitory effects of (-)-epigallocatechin gallate on spontaneous hepatoma in C3H/NeNCrj mice and human hepatoma-derived PLC/PRF/5 cells, Jpn. J. Cancer Res. 85(3): 221–225 (1994).Google Scholar
  24. 24.
    Yin, P., Zhao, J., Cheng, S., Hara, Y, Zhu, Q., Liu, Z., Experimental studies of the inhibitory effects of green tea catechin on mice large intestinal cancers induced by 1,2-dimethylhydrazine, Cancer Lett. 79: 33–38 (1994).CrossRefGoogle Scholar
  25. 25.
    WHO International Agency for Research on Cancer, IARC Monogor. Eval. Carcinog. Risk Hum. 51: 207–271 (1991).Google Scholar
  26. 26.
    Wakai, K., Ohno, Y, Obata, K., Aoki, K., Prognostic significance of selected lifestyle factors in urinary bladder cancer, Jpn. J. Cancer Res. 84(12): 1223–1229 (1993).Google Scholar
  27. 27.
    Shibata, A., Mack, T. M., Paganini, H. A., Ross, R. K., Henderson, B. E., Aprospective study of pancreatic cancer in the elderly, Int J Cancer 58: 46–49 (1994).CrossRefGoogle Scholar
  28. 28.
    Gao, Y. T., McLaughlin, J. K., Blot, W. J., Ji, B. T., Dai, Q., Fraumeni, J. J., Reduced risk of esophageal cancer associated with green tea consumption, J Natl. Cancer Inst. 86: 855–858 (1994).CrossRefGoogle Scholar
  29. 29.
    Mellemgaard, A., Engholm, G., McLaughlin, J. K., Olsen, J. H., Risk factors for renal cell carcinoma in Denmark I. Role of socioeconomic status, tobacco use, beverages and family history, Cancer Causes Control 5(2): 105–113 (1994).CrossRefGoogle Scholar
  30. 30.
    Hu, J., Nyren, O., Wolk, A., Bergstrom, R., Yuen, J., Adami, H. O., Guo, L., Li, H., Huang, G., Xu, X., Risk factors for esopahgeal cancer in northeast China, Int. J. Cancer 57(l): 38–46 (1994).CrossRefGoogle Scholar
  31. 31.
    Slattery, M. L., West, D. W., Smoking, alcohol, coffee, tea, caffeine and theobromine: risk of prostate cancer in Utah (United States), Cancer Causes Control 4(6): 559–563 (1993).CrossRefGoogle Scholar
  32. 32.
    Ewertz, M., Breast cancer in Denmark. Incidence risk factors, and characteristics of survival, Acta. Oncol. 32(6): 595–615(1993).CrossRefGoogle Scholar
  33. 33.
    Dhar, G. M., Shan, G. N., Naheed, B., Hafiza, Epidemiological trend in the distribution of cancer in Kashmir Valley, J. Epidemiol Community Health 47: 290–292 (1993).CrossRefGoogle Scholar
  34. 34.
    Hansson, L. E., Nyren, O., Bergstrom, R., Wolk, A., Lmdgren, A., Baron, J., Adami, H. O., Diet and risk of gastric cancer. A population-based case-control study in Sweden, Int J Cancer 55: 181–189 (1993).CrossRefGoogle Scholar
  35. 35.
    Olsen, J., Kronborg, O., Coffee, tobacco and alcohol as risk factors for cancer and adenoma of the large intestine, Int. J Epidemiol. 22(3): 398–402 (1993).CrossRefGoogle Scholar
  36. 36.
    Mashberg, A., Boffetta, P., Winkelman, R., Garfinkel, L., Tobacco smoking, alcohol drinking, and cancer of the oral cavity and oropharynx among U.S. veterans, Cancer 72(4): 1369–1375 (1993).CrossRefGoogle Scholar
  37. 37.
    Zatonski, W. A., Boyle, P., Przewozniak, K., Maisonneuve, P., Drosik, K., Walker, A. M., Cigarette smoking, alcohol, tea and coffee consumption and pancreas cancer risk: a case-control study from Opole, Poland, Int. J. Cancer 53(4): 601–607 (1993).CrossRefGoogle Scholar
  38. 38.
    Huang, C, Zhang, X., Qiao, Z., Guan, L., Peng, S., Liou, J., Xie, R., Zheng, L., A case-control study of dietary factors in patients with lung cancer, Biomed. Environ. Sci. 5(3): 257–265 (1992).Google Scholar
  39. 39.
    Memik, F., Nak, S. G., Gülten, M., Ozturk, M., Gastric carcinoma in northwestern Turkey: epidemiologic Characteristics, J Environ. Pathol. Toxicol. Oncol. 11: 335–338 (1992).Google Scholar
  40. 40.
    Mizuno, S., Watanabe, S., Nakamura, K., Omata, M., Oguchi, H., Ohashi, K., Ohyanagi, H., Fujiki, T., Motojima, K., A multi institute case-control study on the risk factors of developing pancreatic cancer, Jpn. J Clin. Oncol. 22(4): 286–291 (1992).Google Scholar
  41. 41.
    Franceschi, S., Serraino, D., Risk factors for adult soft tissue sarcoma in northern Italy, Ann Oncol. 3(2): 85–88 (1992).Google Scholar
  42. 42.
    Baron, J. A., Gerhardsson de Verdier, M., Ekbom, A., Coffee, tea, tobacco, and cancer of the large bowel, Cancer Epidemiol. Biomarkers Prev. 3: 565–570 (1994).Google Scholar
  43. 43.
    Segi, M., Tea-gruel as a possible factor for cancer of the esophagus, Gann 66: 199–202 (1975).Google Scholar
  44. 44.
    Joint Iran-International Agency for Research on Cancer Study Group. Esophageal cancer studies in the Caspian Littoral of Iran: results of population studies-a prodrome, J Natl Cancer Inst. 59: 1127–1138 (1977).Google Scholar
  45. 45.
    Kapadia, G. J., Rao, S., Morton, J. R, Herbal tea consumption and esophageal cancer, In: Carcinogens and Mutagens in the Environment, (Stich, H. F., ed.), 3, pp. 3–12, CRC Press. Inc., Boca Raton, Florida, (1983).Google Scholar
  46. 46.
    Victora, C. G., Munoz, N., Day, N. E., Barcelos, I. B., Pecein, D. A., Braga, N. M., Hot beverages and oesophageal cancer in southern Brazil: a case-control study, Int. J. Cancer 39: 710–716 (1987).CrossRefGoogle Scholar
  47. 47.
    La Vecchia, C, Negri, E., Franceschi, S., D’Avanzo, B., Boyle, P., Tea consumption and cancer risk, Ntr. Cancer 17: 27–31 (1992).CrossRefGoogle Scholar
  48. 48.
    Kaufman, B. D., Liberman, I. S., Tyshetsky, V. I., Some data concerning the incidence of oesophageal cancer in the Gurjev region of the Kazakh SSR (Russ.), Vopr. Onkol 11: 78–85 (1965).Google Scholar
  49. 49.
    Bashirov, M. S., Nugmanov, S. N., Kolycheva, N. I., Epidemiological study of oesophageal cancer in the Akhtubinsk region of the Kazakh Socialist Republic (Russ.), Vopr. Onkol. 14: 3–7 (1968).Google Scholar
  50. 50.
    Cook-Mozaffari, P. J., Azordegan, F., Day, N. E., Ressicaud, A., Sabai, C, Aramesh, B., Oesophageal cancer studies in the Caspian Littoral of Iran: results of a case-control study, Br. J. Cancer 39: 293–309 (1979).CrossRefGoogle Scholar
  51. 51.
    Stocks, P., Cancer mortality in relation to national consumption of cigarettes, solid fuel, tea and coffee, Br. J. Cancer 24: 215–225 (1970).CrossRefGoogle Scholar
  52. 52.
    Oguni, I., Chen, S. J., Lin, P. Z., Hara, Y., Protection against cancer risk by Japanese green tea, Prevent. Med. 21: 332 (1992).Google Scholar
  53. 53.
    Kinlen, L. J., McPherson, K., Pancreas cancer and coffee and tea consumption: a case-control study, Br. J. Cancer 49: 93–96 (1984).CrossRefGoogle Scholar
  54. 54.
    Graham, S., Lilienfeld, A. M., Tidings, J. E., Dietary and purgation: factors in the epidemiology of gastric cancer, Cancer 20: 2224–2234 (1967).CrossRefGoogle Scholar
  55. 55.
    Higginson, J., Etiological factors in gastrointestinal cancer in man, J. Natl. Cancer Inst. 37: 527–545 (1966).Google Scholar
  56. 56.
    Tajima, K., Tominaga, S., Dietary habits and gastro-intestinal cancers: a comparative case-control study of stomach and large intestinal cancers in Nagoya, Jpn. J. Cancer Res. (Gann) 76: 705–716 (1985).Google Scholar
  57. 57.
    Trichopoulos, D., Ouranos, G., Day, N. E., Tzonou, A., Manousos, O., Papadimitriou, C, Trichopoulos, A., Diet and cancer of the stomach: a case-control study in Greece, Int. J. Cancer 36: 291–297 (1985).Google Scholar
  58. 58.
    Agudo, A., Gonzalez, C. A., Marcos, G., Sanz, M., Saigi, E., Verge, J., Boleda, M., Ortego, J., Consumption of alcohol, coffee, and tobacco, and gastric cancer in Spain, Cancer Causes Control 3(2): 137–143 (1992).CrossRefGoogle Scholar
  59. 59.
    Demirer, T., Icli, F., Uzunalimoglu, O., Kucuk, O., Diet and stomach cancer incidence. A case-control study in Turkey, Cancer 65(10): 2344–2348 (1990).CrossRefGoogle Scholar
  60. 60.
    Lee, H. H., Wu, H. Y, Chuang, Y C, Chang, A. S., Chao, H. H., Chen, K. Y, Chen, H. K., Lai, G. M., Huang, H. H., Chen, C. J., Epidemiologic characteristics and multiple risk factors of stomach in Taiwan, Anticancer Res. 10(4): 875–881 (1990).Google Scholar
  61. 61.
    Kono, S., Green tea and colon cancer, Jpn. J. Cancer Res. 83(6): 669 (1992).Google Scholar
  62. 62.
    Yu, G. P., Hsie, C. C, Risk factors for stomach cancer: a population-based case-control study in Shanghai, Cancer Causes Control 2: 169–174 (1991).CrossRefGoogle Scholar
  63. 63.
    Lee, M.-J., Wang, Z.-Y, Li, H., Chen, L., Sun, Y, Gobbo, S., Balentine, D. A., Yang, C. S., Analysis of plasma and urinary tea polyphenols in human subjects, Cancer Epidemiol. Biomark. Prev. 4: 393–399 (1995).Google Scholar
  64. 64.
    Yamane, T., Hagiwara, N., Tatcishi, M., Akachi, S., Kim, M., Okuzuni, J., Kitao, Y, Inagake, M., Kuwata, K., Takahashi, T., Inhibition of azoxymethane-induced colon carcinogenesis in rat by green tea polyphenol fraction, Jpn. J. Cancer Res. 82: 1336–1339 (1991).Google Scholar
  65. 65.
    Narisawa, T., Fukaura, Y, A very low dose of green tea polyphenols in drinking water prevents N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats, Jpn. J. Cancer Res. 84: 1007–1009 (1993).Google Scholar
  66. 66.
    Shiraki, M., Hara, Y, Osawa, T., Kumon, H., Nakayama, T., Kawakishi, S., Antioxidative and antimutagenic effects of theaflavins from black tea, Mutat. Res. 323: 29–34 (1994).CrossRefGoogle Scholar
  67. 67.
    Wang, Z. Y, Khan, W A., Bickers, D. R., Protection against polycyclic aromatic hydrocarbon-induced skin tumor initiation in mice by green tea polyphenols, Carcinogenesis 10: 411–415 (1989).CrossRefGoogle Scholar
  68. 68.
    Chen, J.-S., The effects of Chinese tea on the occurrence of esophageal tumors induced by N-itrosomethylbenzylamine in rats, Prev. Med. 21: 385–391 (1992).CrossRefGoogle Scholar
  69. 69.
    Khan, S. G., Katiyar, S. K., Agarwal, R., Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention, Cancer Res. 52: 4050–4052 (1992).Google Scholar
  70. 70.
    Sohn, O. S., Surace, A., Fiala, E. S., Richie, J. P. J., Colosimo, S., Zang, E., Weisburger, J. H., Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat, Xenobiotica 24: 119–127(1994).Google Scholar
  71. 71.
    Bu-Abbas, A., Clifford, M. N., Walker, R., Ioannides, C, Selective induction of rat hepatic CYP1 and CYP4 proteins and of peroxisomal proliferation by green tea, Carcinogenesis 15: 2575–2579 (1994).CrossRefGoogle Scholar
  72. 72.
    Cerutti, P. A., Mechanisms of action of oxidant carcinogens, Cancer Detection and Prevention 14: 281–284 (1989).Google Scholar
  73. 73.
    Feig, D. I., Reid, T. M., Loeb, L. A., Reactive oxygen species in tumorigenesis, Cancer Res. 54 (Suppl.): 1890s–1894s (1994).Google Scholar
  74. 74.
    Huang, M.-T., Ho, C.-T., Wang, Z.-Y, Ferraro, T., Finnegan-Oliver, T., Lou, Y-R., Mitchell, J. M., Laskin, J. D., Newmark, H., Yang, C. S., Conney, A. H., Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin, Carcinogenesis) 13: 947–954 (1992).CrossRefGoogle Scholar
  75. 75.
    Wang, Z.-Y, Agarwal, R., Bickers, D. R., Mukhtar, H., Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols, Carcinogenesis 12: 1527–1530 (1991).CrossRefGoogle Scholar
  76. 76.
    Yoshizawa, S., Horiuchi, T., Sugimura, M., Penta-o-galloyl-ß-D-glucose and (-)-epigallocatechin gallate: cancer prevention agent, in: Phenolic Compounds in Foods and Health II: Antioxidant & Cancer Prevention (Huang, M.-T., Ho, C.-T., Lee, C. Y, eds.), pp. 316–325, American Chemical Society, Washington, D. C., (1992).CrossRefGoogle Scholar
  77. 77.
    Katiyar, S., Agarwal, R., Wood, G. S., Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7, 12-dimethylbenz(a)anthracene-initiated SENCAR mouse skin by a polyphenols fraction isolated from green tea, Cancer Res. 52: 6890–6897 (1992).Google Scholar
  78. 78.
    Khan, W. A., Wang, Z. Y, Athar, M., Bickers, D. R., Mukhtar, H., Inhibition of the skin tumorigenicity of (±)7ß, 8α-epoxy-7, 8, 9, 10-tetrahydrobenzo(a)pyrene by tannic acid, green tea polyphenols and quercetin in Senear mice, Cancer Letters 42: 7–12 (1988).CrossRefGoogle Scholar
  79. 79.
    Shimamura, T., Inhibition of influenza virus infection by tea polyphenols, in: Food Phytochemicals for Cancer Prevention II (Huang, M.-T., Osawa, T., Ho, C.-T., Rosen, R. T., eds.), pp. 97–101, ACS Symposium Series 546, Washington, D.C., (1992).Google Scholar
  80. 80.
    Yan, Y S., Effect of Chinese tea extract on the immune function of mice bearing tumor and their antitumor activity, Chung Hua Yu Fang I Hsueh Tsa Chih 26: 5–7 (1992).Google Scholar
  81. 81.
    Nakamamura, M., Kawabata, T., Effect of Japanese green tea on nitrosamine formation in vitro, J. Food Sci. 46: 306–307(1981).Google Scholar
  82. 82.
    Stich, H. F., Teas and tea components as inhibitors of carcinogen formation in model system and man, Prev. Med. 21: 377–384 (1992).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Chung S. Yang
    • 1
  • Laishun Chen
    • 1
  • Mao-Jung Lee
    • 1
  • Janelle M. Landau
    • 1
  1. 1.Laboratory for Cancer Research College of PharmacyRutgers UniversityPiscatawayUSA

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