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Antitumorigenic Effects of Limonene and Perillyl Alcohol Against Pancreatic and Breast Cancer

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Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 401)

Abstract

Perillyl alcohol is a natural product from cherries and other edible plants. Perillyl alcohol and d-limonene, a closely related dietary monoterpene, have chemotherapeutic activity against pancreatic, mammary, and prostatic tumors. In addition, perillyl alcohol, limonene, and other dietary monoterpenes have chemopreventive activity. Several mechanisms may account for the antitumorigenic effects of monoterpenes. For example, many monoterpenes inhibit the post-translational isoprenylation of cell growth-regulatory proteins such as Ras. Perillyl alcohol induces apoptosis without affecting the rate of DNA synthesis in both liver and pancreatic tumor cells. In addition, monoterpene-treated, regressing rat mammary tumors exhibit increased expression of transforming growth factor β concomitant with tumor remodeling/redifferentiation to a more benign phenotype. Monoterpenes are effective, nontoxic dietary antitumor agents which act through a variety of mechanisms of action and hold promise as a novel class of antitumor drugs for human cancer.

Keywords

  • Chemopreventive Activity
  • Pancreatic Tumor Cell
  • Perillyl Alcohol
  • Chemotherapeutic Activity
  • Antitumorigenic Effect

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1996 Plenum Press, New York

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Crowell, P.L., Ayoubi, A.S., Burke, Y.D. (1996). Antitumorigenic Effects of Limonene and Perillyl Alcohol Against Pancreatic and Breast Cancer. In: Dietary Phytochemicals in Cancer Prevention and Treatment. Advances in Experimental Medicine and Biology, vol 401. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0399-2_10

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  • DOI: https://doi.org/10.1007/978-1-4613-0399-2_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8034-4

  • Online ISBN: 978-1-4613-0399-2

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