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Autologous BMT for Treatment of Experimental Autoimmune Diseases

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Molecular Biology of Hematopoiesis 5

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Abstract

For many experimental autoimmune diseases (AID) the predisposition to the disease was shown to reside in the bone marrow (BM) as recently reviewed by Van Bekkum (1) and Marmont (2). Like in individual humans, genetically different inbred rodent strains vary in their susceptibility to experimentally induced AID. The permanent engraftment of BM from susceptible animals in lethally irradiated resistant animals rendered the recipients suscepti¬ble, and vice versa. The finding that the transplantation of purified hemopoietic stem cells from spontanously autoimmune-prone NZB and (NZW x BXSB) F1 mice into normal mice led to the development of AID in the recipients, suggested that genetic defects residing in the hemopoietic stem cell determine the development of AID in the case of the hereditary forms (3,4). Factors like sex and environment (5,6,7) appear to act only as modulating factors.

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Authors and Affiliations

  1. IntroGene B.V, P.O. Box 3271, 2280, GG Rijswijk, The Netherlands

    D. W. van Bekkum & M. van Gelder

Authors
  1. D. W. van Bekkum
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  2. M. van Gelder
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Editor information

Editors and Affiliations

  1. The Rockefeller University, New York, New York, USA

    Nader G. Abraham

  2. University of Tokyo, Tokyo, Japan

    Shigetaka Asano

  3. Universität-Gesamthoschschule Essen, Essen, Germany

    Günther Brittinger

  4. Istituto Cantonale di Patologia, Locarno, Switzerland

    Georges J. M. Maestroni

  5. Western Pennsylvania Cancer Institute, Pittsburgh, Pennsylvania, USA

    Richard K. Shadduck

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© 1996 Plenum Press, New York

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van Bekkum, D.W., van Gelder, M. (1996). Autologous BMT for Treatment of Experimental Autoimmune Diseases. In: Abraham, N.G., Asano, S., Brittinger, G., Maestroni, G.J.M., Shadduck, R.K. (eds) Molecular Biology of Hematopoiesis 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0391-6_9

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  • DOI: https://doi.org/10.1007/978-1-4613-0391-6_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8031-3

  • Online ISBN: 978-1-4613-0391-6

  • eBook Packages: Springer Book Archive

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