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Is there an Embryological Basis for the Association of Mediastinal Germ Cell Tumors and Hematologic Cancers?

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Molecular Biology of Hematopoiesis 5

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Abstract

The unexpectedly frequent association of germ cell tumors and hematologic cancers raises a question about the developmental relationship between primordial germ cells (PGCs) and hematopoietic stem cells (HSCs). It has been known for many years that the primordial germ cells of the primitive gonad arise from the yolk sac and that the yolk sac is also the first site of blood formation. It has also become clear that the development of these two apparently disparate cell types is dependent on some of the same factors; c-kit ligand and c-kit receptor are among the most intriguing.

Even more relevant, perhaps, are recent studies investigating the very early development of the PGCs and HSCs in mammals. This new information raises alluring questions concerning the relationship between the ultimate progenitors of these cells which may also be pertinent to the unusual clinical association of germ cell and hematologic malignancies in humans.

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Author information

Authors and Affiliations

  1. Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, USA

    William J. Larsen

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  1. William J. Larsen
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Editor information

Editors and Affiliations

  1. The Rockefeller University, New York, New York, USA

    Nader G. Abraham

  2. University of Tokyo, Tokyo, Japan

    Shigetaka Asano

  3. Universität-Gesamthoschschule Essen, Essen, Germany

    Günther Brittinger

  4. Istituto Cantonale di Patologia, Locarno, Switzerland

    Georges J. M. Maestroni

  5. Western Pennsylvania Cancer Institute, Pittsburgh, Pennsylvania, USA

    Richard K. Shadduck

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© 1996 Plenum Press, New York

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Larsen, W.J. (1996). Is there an Embryological Basis for the Association of Mediastinal Germ Cell Tumors and Hematologic Cancers?. In: Abraham, N.G., Asano, S., Brittinger, G., Maestroni, G.J.M., Shadduck, R.K. (eds) Molecular Biology of Hematopoiesis 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0391-6_8

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  • DOI: https://doi.org/10.1007/978-1-4613-0391-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8031-3

  • Online ISBN: 978-1-4613-0391-6

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