Advertisement

Mantle Cell Lymphoma

Genetic Lesions and Their Role in Classification and Progression
  • G. Ott
  • M. M. Ott
  • J. Kalla
  • A. Helbing
  • B. Schryen
  • T. Katzenberger
  • J. Bartek
  • A. Dürr
  • J. G. Müller
  • H. Kreipe
  • H. K. Müller-Hermelink
Chapter

Abstract

Mantle cell lymphoma, a tumor derived from CD5-positive virgin B-cells of the follicular mantle zone, accounts for 5–10% of non-Hodgkin’s lymphomas in adults (Banks et al. 1992, Harris et al. 1994). It was originally described in the Kiel classification (Stansfeld et al. 1974) as centrocytic lymphoma.

Keywords

Mantle Cell Lymphoma Pleomorphic Type Pleomorphic Variant Classical Cytogenetic Numerical Chromosome Aberration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Banks PM, Chan J, Cleary ML, Delsol G, de Wolf-Peeters C, Gatter K, Grogan TM, Harris NL, Isaacson PG, Jaffe ES, Mason D, Pileri S, Ralfkiaer E, Stein H, Warnke RA (1992). Mantle cell lymphoma: a proposal for unification of morphologic, immunologic, and molecular data. Am J Surg Pathol 16: 637 – 640PubMedCrossRefGoogle Scholar
  2. Brittinger G (1983) Klinik der malignen Non-Hodgkin-Lymphome, speziell der chronischen lymphatischen Leukämie. Verh-Dtsch-Ges-Pathol. 67: 494 – 516PubMedGoogle Scholar
  3. Fisher RI, Dahlberg S, Nathwani BN, Banks PM, Miller TP, Grogan TM (1995) A clinical analysis of two indolent lymphoma entities: mantle cell lymphoma and marginal zone lymphoma (including the mucosa-associated lymphoid tissue and monocytoid B-cell subcategories): A Southwest Oncology Group study. Blood 85: 1075 - 1082.PubMedGoogle Scholar
  4. Gerard-Marchant R, Hamlin I, Lennert K, Rilke F, Stansfeld AG, van Unnik JAM (1974): Classification of non-Hodgkin’s lymphomas. Lancet 2: 406 – 408Google Scholar
  5. Harris NL, Jaffe ES, Stein H et al. (1994) A revised European-American classification of lymphoid neoplasms: A proposal from the international lymphoma study group. Blood 84: 1361 – 1392.PubMedGoogle Scholar
  6. Lardelli P, Bookman MA, Sundeen J, Longo DL, Jaffe ES (1990)Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunologic spectrum and clinical correlations. Am J Surg Pathol 14: 752–763Google Scholar
  7. Lennert K (1978). Lymphomas of germinal-center cells. In: Lennert K (ed) Malignant lymphomas other than Hodgkin’s disease. Springer, Berlin Heidelberg New York, pp 281 – 345Google Scholar
  8. Lukas J, Pagano M, Staskova Z, Draetta G, Bartek J. (1994). Cyclin Dl protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene 9: 707 – 718PubMedGoogle Scholar
  9. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ (1991) Colony-Stimulating Factor 1 regulates novel cyclins during the Gl phase of the cell cycle. Cell 65: 701 – 713.PubMedCrossRefGoogle Scholar
  10. Ott MM, Ott G, Kuse R, Porowski P, Gunzer U, Feller AC, Müller-Hermelink HK (1994) The anaplastic variant of centrocytic lymphoma is marked by frequent rearrangements of the bel-1 gene and high proliferation indices. Histopathology 24: 329 - 334PubMedCrossRefGoogle Scholar
  11. Ott MM, Helbing A, Ott G, Bartek J, Fischer L, Dürr A, Kreipe H, Müller-Hermelink HK. (1996a) Bcl-1 gene rearrangement and Cyclin Dl protein expression in mantle cell lymphoma. J Pathol 179: 238 – 242.CrossRefGoogle Scholar
  12. Ott G, Kalla J, Ott MM, Schryen B, Katzenberger T, Müller JG,Müller-Hermelink HK. (1996b) Blastoid variants of mantle cell lymphoma: Frequent bcl-1 rearrangements at the MTC locus and tetraploid chromosome clones. Submitted for publication.Google Scholar
  13. Stein H, Lennert K, Feller AC, Mason DY (1984) Immunohistochemical analysis of human lymphoma: Correlation of histological and immunological categories. Adv Cancer Res 42: 67 – 147PubMedCrossRefGoogle Scholar
  14. Tilly H, Rossi A, Stamatoullas A, Lenormand B, Bigorgne C, Kunlin A, Monconduit M, Bastard C. (1994) Prognostic value of chromosomal abnormalities in follicular lymphoma. Blood 84: 1043 – 1049PubMedGoogle Scholar
  15. Williams ME, Meeker TC, Swerdlow SH ( 1991 Rearrangement of the chromosome 11 bcl-1 locus in centrocytic lymphoma: analysis with multiple breakpoint probes. Blood 76: 1387 – 1391Google Scholar

Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • G. Ott
    • 1
    • 2
  • M. M. Ott
    • 1
  • J. Kalla
    • 1
  • A. Helbing
    • 1
  • B. Schryen
    • 1
  • T. Katzenberger
    • 1
  • J. Bartek
    • 3
  • A. Dürr
    • 1
  • J. G. Müller
    • 1
  • H. Kreipe
    • 1
  • H. K. Müller-Hermelink
    • 1
  1. 1.Institute of PathologyUniversity of WürzburgGermany
  2. 2.Pathologisches InstitutUniversität WürzburgWürzburgGermany
  3. 3.Division of Cancer BiologyDanish Cancer SocietyCopenhagenDenmark

Personalised recommendations