Monitoring of Serum HLA Class I Antigen Levels in Allogeneic Bone Marrow Transplantation
The levels of serum HLA Class I antigens were determined at weekly intervals up to five weeks in thirty-eight patients who had undergone allogeneic BMT. In patients with GVHD grade I serum HLA Class I antigen levels did not change during the observation period. In patients with GVHD grade II – IV serum HLA Class I antigen level increased in the week before the onset of GVHD and was maximal during the GVHD episode. The mean ± SEM concentrations of serum HLA Class I antigens during GVHD grade II – IV episodes (6.3 ±1.1 jig/ml) is significantly higher than in the first week after BMT (2.5 ± 0.3 lng/ml) and in the week preceding the GVHD episode (3.5 ± 0.4 ug/ml) (P = 0.0002 and P = 0.01, respectively). The results of the present investigation suggest that measure of serum HLA Class I antigen level may be a useful marker to detect an acute GVHD following BMT.
KeywordsGraft Versus Host Disease Antigen Level Allogeneic Bone Marrow Transplantation Bone Marrow Transplantation Recipient Acute Graft Versus Host Disease
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