A Method for the in Vivo Quantitation of Angiogenesis in the Rabbit Corneal Model

  • Robert W. Shaffer
  • Martin Friedlander
Part of the NATO ASI Series book series (NSSA, volume 285)


Angiogenesis is stimulated by a variety of factors and underlies the pathology of many disease states, including cancer and blinding eye disease. It is often necessary to quantitate the angiogenic response to various stimuli and determine the efficacy of putative inhibitory agents. We describe a non-invasive method for measuring angiogenesis in a rabbit corneal model with precision and ease, regardless of geometrical irregularities in the vessel growth pattern.


Vascular Endothelial Growth Factor Diabetic Retinopathy Angiogenic Response Vessel Growth Vessel Length 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • Robert W. Shaffer
    • 1
  • Martin Friedlander
    • 1
  1. 1.Department of Cell BiologyThe Scripps Research InstituteLa JollaUSA

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